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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Determination of circulation factors that mediate the health benefits of exercise in mitochondrial aging

    SBC: CYTEGEN CORP            Topic: NIA

    Project Summary/Abstract: This proposal seeks to test the hypothesis that endurance exercise stimulates the release of circulating factors that improve mitochondrial fitness. CyteGen’s goal is to identify these endogenous factors and engineer them to treat diseases in which mitochondrial dysfunction is central. These diseases include neurodegenerative and other diseases associated with aging, as ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Preclinical proof of concept validation of a novel endoscopic treatment for urethral stricture disease

    SBC: Celeflux LLC            Topic: 400

    PROJECT SUMMARY/ABSTRACT CeleFlux is developing a medical device which enables urologists to provide long-lasting, minimally invasive urethral reconstruction to treat male urethral stricture - via endoscopic delivery of a temporary tissue graft implant. Urethral stricture disease progressively narrows the urethral lumen, similar to a band of scar tissue. This results in painful and frequent urinat ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Improving data capture in clinical research using a chatbot

    SBC: Dokbot, LLC            Topic: NLM

    PROJECT SUMMARY . Collecting complete and accurate outcome data directly from research participants is becoming increasingly important. Clinical researchers needs a cost-effective approach to capture high-quality patient-reported outcomes. Typically, data captured directly from participants is through self-administered questionnaires or through a human interviewer, each with their own advantages ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. OBJECTIVE HOME MANAGEMENT OF PEDIATRIC ASTHMA EXACERBATION USING MOBILE TECHNOLOGY AND MACHINE LEARNING

    SBC: AUSCULTECH DX LLC            Topic: 600

    PROJECT SUMMARY Asthma is the most common chronic pediatric disease in the United States, affecting 6.2 million or 1 in 12 children. Despite advances in the management of childhood asthma, asthma exacerbation results in approximately 550,000 emergency department (ED) visits, 80,000 hospitalizations, and hundreds of premature deaths each year. Early symptoms of asthma exacerbation, especially in ch ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Feelix @ Home: Testing and optimization of a smart stethoscope for home use to monitor changes in lung status of individuals with chronic conditions

    SBC: SONAVI LABS INC            Topic: NHLBI

    Project SummaryThe goal of this project is to further develop an existing smart stethoscope in order to be capable of monitoring pediatric patients at home who suffer from asthma as well as adults with COPD. Lung diseases impose a serious burden on healthcare systems, individuals and governments. The World Health Organization (WHO) found that chronic obstructive pulmonary disease (COPD) and lower ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Analysis of new compounds to treat familial hypercholesterolemia

    SBC: GRUTHAN BIOSCIENCE LLC            Topic: NHLBI

    PROJECT SUMMARY The long-term goal of the current proposal is to generate a new class of small molecules to treat familial hypercholesterolemia. Familial hypercholesterolemia (FH) patients suffer from excessively high levels of Low Density Lipoprotein Cholesterol (LDL-C), which if left untreated results in death from severe cardiovascular disease. FH is caused primarily by mutations in the LDL rec ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Aminonaphthyridine compounds as potential therapeutics for lung and thyroid cancers

    SBC: KinaRx, LLC            Topic: 102

    Over the past three decades a growing number of cancer-driving protein kinases have been successfully targeted as reflected in the approval of 49 kinase inhibitors by the Food and Drug Administration (FDA). Recent approval of the first tyrosine kinase inhibitor (Larotrectinib) for treatment of any cancer bearing mutation in neurotrophic receptor kinase validated a novel paradigm of precision targe ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Optimization of the UValidate platform to measure genotoxicity associated with current problematic UV chemical blockers

    SBC: Amelia Technologies LLC            Topic: R

    STTR 608040: Optimization of the UValidate platform to measure genotoxicity associated with current problematic UV chemical blockers Optimization of the UValidate™ platform to measure genotoxicity associated with current problematicUV chemical blockers. Project Summary/ Abstract(word count: 375) Over-the-counter active ingredients that block UVA and UVB are required in all sunscreens, as mandate ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Delivery of chemically modified PNA oligomers

    SBC: NUBAD, LLC            Topic: NIAID

    PROJECT SUMMARYRNA is a validated target for drug design, both as therapeutic and as a target. Targeting specific RNA, such as rRNA which are involved in proliferation and survival of bacteria is a promising approach. We are developing fast and low cost methods to screen sequence-specific small molecules for novel anti-ribosomal activities. We will construct sequence-specific chemically modified r ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Programming Metabolically Fit TILs for Immunotherapy

    SBC: Lipo-immuno Tech, LLC            Topic: NCI

    ABSTRACT Advances in molecular biology and genetic engineering have led to the design and use of modified T cells recognize tumors to achieve significant tumor control upon adoptive cell transfer (ACT) to patients. These T cells are either transduced with tumor antigen reactive T cell receptors (TCR), or chimeric antigen receptors (CARs). Recently, a surge in studies with neo-antigen reactive T ce ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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