Award Data

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is to enhance the health of livestock without addition of synthetic antibiotic and antioxidant compounds. The proposed technologies are corn kernel fiber byproducts of ethanol production from corn. The need for such compounds has grown as livestock is now more often raised in concentrated animal feedi ...

Filovirusesconsisting of two major virus families including the ebolaviruses and marburgvirusesMARV and RAVVcause periodic outbreaks of severe viral hemorrhagic fever with mortality rates as high asSince it is difficult to predict the species that would dominate future outbreaksdevelopment of broadly protective therapeutics to prevent and manage future filovirus outbreaks is of high priorityIn sha ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to enable affordable manufacturing process for aerogel, an ultralight structural material that can reduce the fuel consumption and emissions of cars, planes, and rockets. Aerogels are a class of ultralight materials exhibiting unparalleled thermal insulation, soundproofing, and energy-absor ...

PROJECT SUMMARYPersonal sound amplification productsPSAPshave recently become available to the publicPSAPs serve a potentially important role in providing audibility of sounds for adults who have difficulty hearing in some daily living situationsbut may not be candidates for traditionalhigh amplification hearing aidsFewer thanof adults with hearing loss reporting use of hearing aidsciting high cos ...

The proposed research will advance preclinical characterization and validation of a novel drug for asthmaA growing body of research has uncovered functional gamma amino butyric acid type A receptorGABAARsignaling in non neuronal cellsOur research has demonstrated that ligands activating GABAAR subtypes located on airway smooth muscle and immune cells reduce airway hyper responsivenessAHRand inflam ...

This Small Business Technology Transfer (STTR) Phase I project supports the development of a medical device that enables minimally invasive graft-based reconstruction of the urethra as a long-lasting treatment for male urethral stricture, a class of conditions causing restrictions in flow. Approximately 1% of men on Medicare are treated for stricture annually, and an estimated 1 in 5 men will get ...

PROJECT SUMMARY Aminoglycosides are one of the cheapest and well known antibiotics in clinical use for over years but one of the major limitations in their use is their ototoxicity We are developing fast and low cost methods to develop aminoglycosides with anti ribosomal activities and reduced toxicity In this project we will identify novel aminoglycoside antibacterials that show reduced ototoxici ...

Complicated GriefCGis a prevalent and debilitating disorder associated with significant distress and impairmentIt differs from major depression in its treatment and symptomatologyCG is listed in DSMas a subtype of Trauma and Greif DisorderThe World Health Organization will include CG as a stand alone disorder in ICDand it is expected that the DSMsubcommittee will follow suitTraditional forms of th ...

The broader/commercial impact of this SBIR Phase I project leverages recent advances in additive manufacturing to solve key technical hurdles and design deficits of current industry standard microcapillary needles. Microinjection is a well-established engineering technique and widely used in research and medical applications such as drug discovery and development, fertility treatments, and genetic ...

The broader/commercial impact of this SBIR Phase I project is to start validating a novel high-intensity focused ultrasound (HIFU) device for minimally invasive treatment of brain tumors. The current standard of care is a highly invasive cranial flap resection, which not only risks infection, uncontrolled bleeding, and damage to healthy tissue, but also has prolonged post-operative recovery. Altho ...