Award Data

DESCRIPTION provided by applicant This proposal includes trade secrets and other proprietary or confidential information of Highland Instruments and is being provided for use by the National Institutes of Health NIH for the sole purpose of evaluating this SBIR proposal No other rights are conferred This proposal and the trade secrets and other proprietary or confidential information contain ...

DESCRIPTION provided by applicant The world is rapidly heading towards a pre andapos s scenario when it comes to fighting infectious disease Antimicrobial resistance is a growing problem on a global scale greatly hampering our abilities to quell worldwide epidemics such as tuberculosis and malaria as well as the simple staphylococcus infection The proposed project is significant and has ...

DESCRIPTION provided by applicant andquot Development of a low cost extended range autorefractorandquot This project proposal seeks to develop technologies that will lower the cost of and increase the accessibility of refractive eye care especially in low resoure settings We propose to advance our previously developed low cost handheld device capable of automati ...

DESCRIPTION provided by applicant Ebola EBOV and Marburg MARV viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as biosafety level agents Currently there is no effective vaccine or therapeutic treatment against f ...

DESCRIPTION provided by applicant Traumatic brain injuries TBI are an area of significant unmet need with no approved therapeutics and a national burden of $ billion annually Astrocyte Pharmaceuticals is developing a small molecule pharmaceutical agent that would be administered by intravenous injection by emergency responders or a medical professional within hours of injury to limit n ...

DESCRIPTION provided by applicant The overall goal of this project is to address the critical medical need for agents to combat antibacterial drug resistance by a novel approach of potentiating drug influx in Gram negative non fermenters such as Pseudomonas aeruginosa and Acinetobacter baumannii These species exhibit intrinsic drug resistance due to the combined effects of a poorly permeable o ...

DESCRIPTION provided by applicant Drug administration is an essential tool in laboratory animal research that enables studies ranging from basic molecular cellular mechanisms to drug discovery to preclinical development of new therapies However there is a significant technological gap in the development of advanced dosing strategies current technologies do not meet the needs of animal care p ...

DESCRIPTION provided by applicant Ebola EBOV and Marburg MARV viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as biosafety level agents Currently there is no effective vaccine or therapeutic treatment against f ...

DESCRIPTION provided by applicant Glucagon is a peptide hormone with a central role in the regulation of glucose metabolism and many disorders including Type and Type diabetes are notable for abnormalities in glucagon levels Both clinical practice and research in this field are hampered by the lack of appropriately specific and sensitive assays for glucagon levels in blood The goal of ...

DESCRIPTION provided by applicant The increasing prevalence of drug resistant bacterial infections highlights the critical medical need for new agents that are not susceptible to existing resistance mechanisms Few new agents are in development for Gram negative bacteria which take up small molecules sparingly and efflux most compounds that reach the periplasm A particularly problematic group ...