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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Cell therapy of diabetes using broad spectrum multipotent stem cells

    SBC: PLUREON CORP.            Topic: N/A

    DESCRIPTION (provided by applicant): Transplantation of insulin-producing cells in many diabetes patients potentially would restore normal glucose homeostasis and prevent the severe long-term complications of the disease. However, the scarcity of donated pancreata currently limits transplantation of the whole organ or of isolated pancreatic islets to a tiny fraction of those patients who might ben ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  2. Antivirals Targeting Flavivirus Envelope Proteins

    SBC: L2 Diagnostics, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop therapeutic antivirals to treat life-threatening flavivirus infections. Enfuvirtide, a clinically successful peptide HIV fusion inhibitor, is the prototype for a new class of antivirals that inhibit viral envelope protein structural rearrangements essential for viral entry into host cells. In preliminary experiment ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  3. Blockade of NF-kappaB for Prevention/Treatment of GVHD

    SBC: THERALOGICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Allogeneic stem cell transplantation (allo-SCT) is potentially curative therapy for a patients suffering from leukemia, lymphoma and multiple myeloma. However, the problems associated with graft-versus-host disease (GVHD) have greatly limited the use of allo-SCT to patients with either an HLA-identical family member or unrelated donor in many transplant centers ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Validation of a Novel NF-KB Inhibitor in Murine IBD

    SBC: THERALOGICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The human inflammatory bowel diseases (IBDs), Crohn's disease (CD) and ulcerative colitis (UC), affect over one million Americans. Until recently, therapies for these disorders have non-specifically suppressed the immune response to inhibit intestinal inflammation. Specific understanding of immune pathways has led to the development of TNF blockade as a treatme ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes

    SBC: VASCULAR PHARMACEUTICALS            Topic: N/A

    DESCRIPTION (provided by applicant): The long term objective of the proposed studies is to develop a monoclonal antibody that can be administered safely to patients with diabetes to determine if it can inhibit atherosclerosis. Insulin-like growth factor-l (IGF-I) has been implicated in initiating the proliferative phase of atherosclerotic lesion development but inhibiting IGF-I receptor activity m ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Recovery /preservation of donation cardiac death livers

    SBC: HEPATOSYS INC            Topic: N/A

    Recovery /preservation of donation cardiac death livers

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  7. Broad-Spectrum Therapeutic Human Antibodies for Dengue Virus Infections

    SBC: L2 Diagnostics, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop antibody therapeutics to treat life-threatening flavivirus infections. Our working hypothesis is that antibodies recognizing specific, highly conserved envelope protein epitopes can prevent and treat infection by several different flaviviruses, including all four serotypes of dengue virus and West Nile virus (WNV). ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  8. Novel High Density Interconnects for Flexible Neural Prostheses

    SBC: PREMITEC, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): To make advanced neural stimulator implant devices such as the artifical retina a reality highly flexible minituarized devices with integrated microelectrode arrays for stimulation and integrated microelectronics are needed. Current prototype devices are still too bulky and have many shortcomings in packaging and interconnects to survive long-term in-vivo. One ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  9. Cloned pigs for Xenotransplantation

    SBC: EVERGEN BIOTECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The purpose of the proposed research is to develop methods to create immune protected universal donor cloned transgenic pigs for xenotransplantation. According to the United Network of Organ Sharing (UNOS) more than 30,000 organ transplants are performed in the US alone, yet greater than 95,000 people are currently on the waiting list to receive donors organs f ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  10. Restoration of Skin Structure and Function Post-Wounding

    SBC: FirstString Research, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): The wound repair process in skin is initiated immediately after an injury and induces a cascade of events including inflammation, proliferation, and scar production/tissue remodeling. One of the common complications of wound healing is excessive scarring, leading to undesirable changes in skin mechanical function, as well as cosmetic disfiguration. The adverse ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
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