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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. HUMAN MONOCOLONAL ANTIBODIES FOR CNS REMYELINATION

    SBC: Acorda Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The primary goal of the current research will be to select the best recombinant form of one of two naturally occurring human igM antibodies demonstrated to stimulate remyelination to further develop for clinical testing in inflammatory demyelinating disease, such as MS. These antibodies, designated sHIgM22 and sHIgM46, were isolated by the Rodriquez laboratory ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  2. Automated Monitoring of Chemotactic Cell Movement

    SBC: APPLIED BIOPHYSICS, INC.            Topic: N/A

    DESCRIPTION ( provided by applicant): The ECIS/taxis technology can detect cells that move to a small electrode through an agarose matrix by the resistance that they impart to an electrical circuit as they cover parts of the small electrode. This system is amenable to rapid throughput analysis of cell behavior in the presence of chemokines and other agents that ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  3. AN EXPANDED GENETIC INFORMATION SYSTEM

    SBC: ERAGEN BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (Aegis), a new, "rule based" molecular recognition system that carries protein ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  4. ESSP Drug Abuse Prevention Screening Tool: Phase II

    SBC: FLYING BRIDGE TECHNOLOGIES            Topic: N/A

    DESCRIPTION (provided by investigator): This application seeks Phase II funding to continue the development of the Elementary School Success Profile (ESSP) Drug Abuse Prevention Sreening Tool. The long-term objective is to help school-based health and mental health professionals quickly and accurately assess students' risk and protective factor status for adolescent substance use and other harmfu ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  5. CHROMOGENIC HER-2/NEU GENE AMPLIFICATION ASSAY

    SBC: NANOPROBES INC            Topic: N/A

    Overexpression of the Her-2/neu protein and amplification of the Her-2/neu gene are are the most widely accepted prognostic indicator of aggressive malignant behavior of invasive breast carcinoma. Accurate detection of Her-2/neu overexpression is critical in identifying patients suitable for serotherapy with humanized monoclonal antibody (Herceptin). Fluorescence in situ hybridization (FISH) has b ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  6. Computerized Campimeter to Measure Central Scotomas

    SBC: OPTICOLOGY, INC.            Topic: N/A

    N/A

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  7. Building Teacher Mastery via an Internet Training System

    SBC: TANGLEWOOD RESEARCH INC            Topic: N/A

    DESCRIPTION (provided by applicant): The purpose of this Phase II STTR is to complete the development of a web-based training system, the All Stars Online Community. This system is designed to improve teachers' delivery of All Stars, an adolescent substance use prevention program. The goal of training is to help teachers advance in their teaching skills and understanding of underlying preventi ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  8. ULTRASENSITIVE METHODS FOR HUMAN BIOMARKER QUANTITATION

    SBC: TRIANGLE LABORATORIES, INC.            Topic: N/A

    Basic research aimed at understanding the complex regulations and interactions lead to various diseases requires novel bioanalytical approaches that allow detailed characterization of the proteome with ultra high-speed and sensitivity so that important regulatory proteins can be effectively studied. For the analysis of complex protein mixtures such as cell lysates, two-dimensional polyacrylamide g ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  9. ASSAYS FOR ROS-INDUCED DNA DAMAGE

    SBC: ZEPTOMETRIX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant):This project is a collaboration between ZeptoMetrix Corporation and Roswell Park Cancer Institute. The objective is to develop sensitive, quantitative and facile assays for measuring DNA damage caused by reactive oxygen species (ROS). ROS have been implicated in aging, cancer and several neurological diseases. Seven ROS-induced DNA lesions will be assayed, namel ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  10. Prevention of corneal transplant rejection using AAV-HLA-G combination therapy

    SBC: Bedrock Therapeutics, Inc.            Topic: NEI

    Abstract Corneal blindness is a leading cause of global blindness, with allogeneic corneal transplantation (CT) being the most common form of tissue transplantation worldwide. Though approximately 180,000 CT surgeries are carried out each year, around 12.7 million are currently awaiting a donor cornea to undergo the operation. Still, CT surgery is accompanied by a high failure rate: as many as 20 ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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