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DESCRIPTION provided by applicant Diffuse large B cell lymphoma DLBCL represents one of the most common variants of Non Hodgkinandapos s lymphoma NHL and oncogenic herpesviruses EBV and KSHV are the etiologic agents for the majority of these tumors in patients over or those infected with the human immunodeficiency virus HIV Despite modest improvements in outcomes for patients rece ...

Historically, aircraft engines have featured relatively simple axisymmetric exhaust shapes with several moving parts; however, future engine exhaust systems are expected feature compact, sinuous ducts with complex non-axisymmetric shapes, fixed exit areas, thrust vectoring etc., constructed with a minimum number of moving parts. Their exhaust plumes are currently not well understood; however, LES ...

We propose to develop a multi-functional coating technology using a three-component nanocomposites to achieve excellent syperhydrophobicity, anti-icing, enhanced track-resistance, and high dielectric breakdown strenght. The coating will be compatible with current Navy existing VLF device materials and be ease of applications in outdoor field, and be long lasting requiring infrequent applications.

In this project, we will develop innovative and advanced display and processing techniques, and innovatively combine existing algorithms, software, and systems, to create a Detection Avoidance System for Submarines (DASS) that assists the submarine operator, planner, and commanding officer (CO) in minimizing the probability that a submarine penetrating into and operating within an A2/AD zone will ...

DESCRIPTION provided by applicant Lipella Pharmaceuticals Inc Pittsburgh PA is a clinical stage pharmaceutical company specializing in intravesical therapies for urinary bladder dysfunctions Lipella is submitting a research proposal to the Small Business Technology Transfer program titled andquot Developing Intravesical Liposomes for Interstitial Cystitisandquot The project proposes to e ...

DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Heart attacks i e myocardial infarction or MI occur in more than million patients annually Advances in pharmacological therapy have dramatically improved survival following the initial MI Consequently the number of patients with previous MI continues to increase and as a result put in jeopardy millions of patients for development of heart failure I ...

DESCRIPTION provided by applicant Self monitoring has been described as the andquot cornerstone of the behavioral treatment of obesityandquot Consistent self monitoring of energy intake is associated with improved dietary adherence and weight loss and maintenance The problem is that individuals are notoriously bad at self monitoring their intake and suffer from an underreporting bias The s ...

The overall goal of this STTR program is to develop an efficient, high-fidelity, CFD-based design tool for the simulation of ship-board flight testing of autonomous UAV systems. In the first phase of this program, an overall flight simulation framework that employs a modular approach to the flight simulation problem was developed. Phase II of the program demonstrated a fully coupled aircraft/ship ...