Award Data

DESCRIPTION provided by applicant Mass spectrometry based proteomics is an emerging technology that has seen possible applications everywhere The technique can potentially use one drop of our blood to reveal onset and progress of diseases Current Randamp D using plasma serum proteome sample sets however is severely limited by the high complexity and dynamic range of protein concentrations ...

DESCRIPTION provided by applicant Metastasis or dissemination of primary tumor cells is the major cause of mortality in cancer patients Circulating tumor cells CTCs in the bloodstream are key players in the establishment of metastatic tumors Recent studies demonstrated that the number of CTCs present in patient blood directly correlate with cancer progression recurrence and survival rate ...

DESCRIPTION provided by applicant The purpose of this Phase II STTR project is to develop a polymeric system for the combination delivery of two antineoplastic agents gemcitabine and paclitaxel Based on the successful results of the STTR Phase I award this Phase II proposal details the rationale and research plan for the synthesis and evaluation of in vivo efficacy of two novel macromolecula ...

DESCRIPTION provided by applicant The measurement monitoring and use of bioelectric signals has evolved from the measurement of the electrical activity of the heart to encompass tissues ranging from cardiac skeletal and smooth muscles to brain and peripheral nerve tissues Together with this development has been the evolution of specialized equipment to capture and interpret these minute sig ...

DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

The broader impact/commercial potential of this project lies in the ability of the Extended Analog Computer (EAC) to perform filtering operations not possible with current technology. The low power, near instantaneous filtering of complex analog signals, differentiates the EAC technology from DSP products currently in the marketplace. The development of prosthetics with advanced control characteri ...

This Small Business Technology Transfer Phase I project will develop a new Present Weather Sensor (PWS). The impact of this project will be felt in the transportation sector where, annually, 1.4 million traffic accidents are caused by weather at an estimated cost to the nation of $42 billion. Knowing whether freezing rain or snow is present greatly influences how Departments of Transportation appr ...

The broader impact/commercialization potential of this Small Business Technology Transfer (STTR) Phase I project is to produce an important platform chemical, hexanoic acid. Currently, the 6-carbon compounds are difficult to attain since crude petroleum contains just a small fraction in this carbon range as part of light naphtha. Most of the 6-carbon compounds are produced via multiple steps that ...

This STTR Phase I project's broader/commercial impact is to produce a replicable education platform that can be applied to many types of higher education courses. The initial commercialization will focus on information systems/information technology courses because it is a content area taught in all major universities and colleges, often in multiple departments. The project is to be designed ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...