Award Data

DESCRIPTION provided by applicant The purpose of this Phase II STTR project is to develop a polymeric system for the combination delivery of two antineoplastic agents gemcitabine and paclitaxel Based on the successful results of the STTR Phase I award this Phase II proposal details the rationale and research plan for the synthesis and evaluation of in vivo efficacy of two novel macromolecula ...

DESCRIPTION provided by applicant Some of the most significant therapies that treat disease target nucleic acids Drugs that target nucleic acid include cancer drugs antibiotics and antivirals Combined these classes of drugs have annual sales worldwide of $ billion Antibiotics that target nucleic acids account for $ billion of the $ billion of sales annuall for all antibiotics an ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Heart attacks i e myocardial infarction or MI occur in more than million patients annually Advances in pharmacological therapy have dramatically improved survival following the initial MI Consequently the number of patients with previous MI continues to increase and as a result put in jeopardy millions of patients for development of heart failure I ...

DESCRIPTION provided by applicant Self monitoring has been described as the andquot cornerstone of the behavioral treatment of obesityandquot Consistent self monitoring of energy intake is associated with improved dietary adherence and weight loss and maintenance The problem is that individuals are notoriously bad at self monitoring their intake and suffer from an underreporting bias The s ...

DESCRIPTION provided by applicant The purpose of this Phase II Small Business Technology Transfer STTR project is to complete development and evaluate usability and effectiveness of the Wraparound Team Monitoring System Wrap TMS a web based electronic behavioral health information system EBHIS for the most widely implemented care coordination model in childrenandapos s behavioral healt ...

DESCRIPTION (provided by applicant): The long-term objective of this application is to develop a wearable multi-sensor way finding device for the visually impaired that can function reliably both indoors and outdoors. The Phase I specific aims are to: 1) assemble and test a hardware platform that consists of a pocket-size computer and four sensors: a wireless signal receiver inside a wearable comp ...

DESCRIPTION (provided by applicant): The wound repair process in skin is initiated immediately after an injury and induces a cascade of events including inflammation, proliferation, and scar production/tissue remodeling. One of the common complications of wound healing is excessive scarring, leading to undesirable changes in skin mechanical function, as well as cosmetic disfiguration. The adverse ...

DESCRIPTION (provided by applicant): The proposed collaborative project assesses the feasibility of integrating a new software module designed to collect, interpret, and manage family history into electronic health record (EHR) systems in a manner that is useful and acceptable to primary care providers and patients. The final product to be developed will be a commercially viable software module ca ...

DESCRIPTION (provided by applicant): The long-term goal of the collaboration between the USC and Southern Sun BioSystems is to create a plant breeding and remediation technology-development center which would supply hardware, protocols for breeding-selection and mass production of elite plants for nurseries and remediation businesses, with licensing and tracking mechanisms for protecting intellect ...