Award Data

PROJECT SUMMARY ABSTRACT During Phase ISealCathLLC will test the feasibility of its innovative Double Balloon CatheterDBCwhich the United States Utility Patent application was approved on Augustand is in the process of issuing a patentLicensed from the Medical University of South Carolinathis DBC will be commercialized in Phase III as the trademarked nameCephus Catheterwith targeted end users bein ...

? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...

DESCRIPTION provided by applicant This proposal seeks to develop a novel vaccine against Lyme disease by targeting Ixodes scapularis proteins critical for Borrelia burgdorferi transmission from the tick to mammalian host Earlier work has identified four tick proteins Salp TRE tHRF and TSLPI that facilitate different steps of spirochete transmission and immunity against these protein ...

Project Summary Human babesiosis is a malaria like multisystem disease caused primarily by Babesia microtian emerging apicomplexan parasite that infects and develops within human erythrocytesThe parasite is transmitted to humans by the tick vector Ixodes scapularis and can also be introduced through blood transfusionInfection can cause flu like symptomsand severe infection can be fatalin particula ...

Abstract The Specific Aim of this Phase I STTR proposal is to test the feasibility of blocking MCJalso called DnaJCto overcome acute acetaminophen liver toxicityAcetaminophen or APAPfrom acetyl paraaminophenolis a common drug used to address pain and feverIn the US aloneaboutpatients per year are admitted to intensive care units with APAP induced liver injury and close toof these patients undergo ...

A Reliable Switched Angle SpinningSASProbe with GradientsPFGfor Proteins in Solid State NMR AbstractSolid state NMRssNMRbiotechnology is emerging as an alternative method of choice for highresolution structure determination for integral membrane proteinsIMPsssNMR provides a unique platform to investigate protein dynamicsand functional studies of wide range of biomolecules in their supramolecular a ...

Xerostomiaor dry mouthaffects approximatelyof the U Spopulationsomemillion people by causing oral discomfort and pain due to chronically dry mucosaThis condition leads to oral disease such as caries and candidiasisand has no cure or adequate treatmentMany remedial approaches have been tried with only limited successincluding the provision of fluid to the mouth via frequent sippingvarious mouthwash ...

Project SummaryAbstract Relatedness to MissionApplication aligns with multipleNINR SBIR goalsGTechnologies to treat chronic wounds that fail to healspecificallydiabetic ulcersBDevices that improve the acceptance and use of assistive devicesBDevices that improve delivery of care to persons who have restricted movement due toperipheralvascular diseaseto allow them to better self manageDTechnologies ...

ABSTRACT BSTRACT In an effort to reduce the use of animals for toxicity testingcompanies have developed bioengineered in vitro skin models to replace the Draize skin irritation testThe development of tissue models has been further pushed by the European Union that prohibited the use of animals infor collecting toxicological data on cosmetic ingredientsSupply of bioengineered tissues is a significa ...

PROJECT SUMMARY Current treatment options for many skin diseases especially rare diseases fail to address the underlying causative pathophysiologiesIn the case of genetic mutations that cause loss of function mutationssupplementing the missing protein is a viable approach to treatmentHoweverdelivery of functional protein to the target keratinocytes presents a significant challengemoreoverthe cost ...