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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A simple assay system for rapid detection of circulating tumor cells

    SBC: TELOVISION, LLC            Topic: NCI

    DESCRIPTION provided by applicant Metastasis or dissemination of primary tumor cells is the major cause of mortality in cancer patients Circulating tumor cells CTCs in the bloodstream are key players in the establishment of metastatic tumors Recent studies demonstrated that the number of CTCs present in patient blood directly correlate with cancer progression recurrence and survival rate ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Peptide Antibiotic Nucleic Acids

    SBC: NUBAD, LLC            Topic: NIAID

    DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Metal ion-functionalized soluble nanopolymers: A new analytical platform for plas

    SBC: Tymora Analytical Operations, LLC            Topic: 300

    DESCRIPTION provided by applicant Mass spectrometry based proteomics is an emerging technology that has seen possible applications everywhere The technique can potentially use one drop of our blood to reveal onset and progress of diseases Current Randamp D using plasma serum proteome sample sets however is severely limited by the high complexity and dynamic range of protein concentrations ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Universal amplifier system for high-fidelity multi-modal biosignal recordings

    SBC: REFER2INPUT, LLC            Topic: 213

    DESCRIPTION provided by applicant The measurement monitoring and use of bioelectric signals has evolved from the measurement of the electrical activity of the heart to encompass tissues ranging from cardiac skeletal and smooth muscles to brain and peripheral nerve tissues Together with this development has been the evolution of specialized equipment to capture and interpret these minute sig ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Enhanced Capacitive Deionization using Carbon Electrodes Conformally Coated with Metal Oxides by Atomic Layer Deposition

    SBC: ALD NANOSOLUTIONS, INC            Topic: 02c

    Access to clean water is a global problem that has led to the development of multiple desalination techniques. All techniques strive to reduce the cost of desalinating water to provide clean water in a cost effective manner. Capacitive deionization (CDI) is a new technique that can reduce the cost of ownership by ~85% compared with reverse osmosis for brackish water. This project will further im ...

    STTR Phase I 2014 Department of Energy
  6. SBIR: Rapid Design and Testing of Novel Gas-Liquid Contacting Devices for Post-Combustion CO2 Capture via 3-D Printing

    SBC: ION Engineering LLC            Topic: 12f

    In order to dramatically reduce CO2 emissions from coal-fired power plants, and mitigate their impact on global climate change, DOE has called for technologies that can capture at least 90% of CO2 emissions from an existing coal-fired power plant with no more than a 35% increase in the cost of electricity (COE). One process design approach with the potential to achieve these goals is through the u ...

    STTR Phase I 2014 Department of Energy
  7. High power diode-pumped laser amplifier for laser-driven ultrafast table-top soft x-ray laser sources

    SBC: XUV Lasers, Inc.            Topic: 08a

    The problem/situation that is being addressed is the development and improvement of compact laser- driven x-ray sources for ultrafast characterization of interest to the DoE. While much progress has been made in the development of table-top x-ray sources, with high harmonic sources and atomic soft x-ray lasers presently allowing for a large number of experiments to be conducted in small laborator ...

    STTR Phase I 2014 Department of Energy
  8. Non-ATP competitive inhibitors of cyclin dependent kinases as cancer therapeutics

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Smartphone Help for DWI Offenders and Their Families: A B-SMART App

    SBC: KLEIN BUENDEL, INC            Topic: NIAAA

    DESCRIPTION (provided by applicant): Driving while intoxicated (DWI) remains a substantial and preventable source of morbidity and mortality in the United States. A variety of sanctions and interventions have been attempted to reduce DWI in the U.S., including enhanced DWI enforcement efforts, stricter drunk driving laws, responsible alcohol beverage service training, and alcohol treatment. The Ig ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Testing Smad7-based biologics for treating chronic wounds

    SBC: TAIGA BIOTECHNOLOGIES INC            Topic: NIAMS

    DESCRIPTION (provided by applicant): Chronic skin wounds associated with various diseases (e.g., diabetes) and aberrant healing from acute wounding (e.g., hypertrophic scarring) is a major health care burden, which need scientific discovery-based therapeutic interventions. Our previous studies show that Smad7, a TGFb signaling antagonist, accelerates skin wound healing. We have developed a Smad7 f ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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