Award Data

DESCRIPTION provided by applicant Metastasis or dissemination of primary tumor cells is the major cause of mortality in cancer patients Circulating tumor cells CTCs in the bloodstream are key players in the establishment of metastatic tumors Recent studies demonstrated that the number of CTCs present in patient blood directly correlate with cancer progression recurrence and survival rate ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Mass spectrometry based proteomics is an emerging technology that has seen possible applications everywhere The technique can potentially use one drop of our blood to reveal onset and progress of diseases Current Randamp D using plasma serum proteome sample sets however is severely limited by the high complexity and dynamic range of protein concentrations ...

DESCRIPTION provided by applicant The measurement monitoring and use of bioelectric signals has evolved from the measurement of the electrical activity of the heart to encompass tissues ranging from cardiac skeletal and smooth muscles to brain and peripheral nerve tissues Together with this development has been the evolution of specialized equipment to capture and interpret these minute sig ...

Sensor Electronic Technology, Inc. proposes to use QD-like fluctuations of InGaN QW with controllable spatial distribution for high efficiency green LEDs. We will investigate both theoretically and experimentally the performance of green InGaN MQW structures with fluctuations of composition and thickness of InGaN quantum wells. Both types of these fluctuations would lead to the spatial localizatio ...

Energy usage will continue to increase at a dramatic pace for the foreseeable future, endangering the security, economy, and environment of the nation. One means of meeting this challenge is the replacement of liquid transportation fuels based on petroleum with cellulosic bioethanol. However, cellulosic ethanol remains too costly to be commercially feasible, in part due to the generation of orga ...

DESCRIPTION (provided by applicant): The integrated scientific team of INphoton, LLC will develop standard operating procedures for intravital multiphoton microscopy assays quantifying fluorescent drug delivery, cellular uptake, intracellular distribution, metabolism, and physiologic/therapeutic effects within the kidney of live rats. Refinement of some existing assays will be necessary for commer ...

DESCRIPTION (provided by applicant): Chronic sleep disturbances are experienced by 40% to 70% of the oldest people in the population, over 65 years. Light treatment devices are available in the market, but they are expensive, are generally glaring because they use inefficient light sources. Further, they require that users be seated in front of the device for at least 30-60 minutes, reducing compl ...

DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...