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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Multi-view, Photon Counting DXA Scanner for Quantitative Musculoskeletal Imaging

    SBC: QUANTUM MEDICAL METRICS, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): The fragility of osteoporotic bones is largely due to alterations in the underlying structural geometry. Research has demonstrated that it is possible to measure the mechanical geometry of human bones in vivo using dualenergy x-ray absorptiometry (DXA) scans. However DXA scanners are designed to measure bone mineral density (BMD) and not structural geometry. Th ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Targeting host response to DAMP for therapy of Rheumatoid Arthritis

    SBC: Oncoimmune Inc            Topic: NIAMS

    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is among the most common autoimmune diseases. The current treatment for RA is mainly by targeting tumor-necrosis factor (TNF). Despite the remarkable efficacy, significant portion of RA patients are not responsive to this class of drugs. Therefore, there is an urgent need to develop therapeutic that can complement existing therapeutic ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Serum GP88 biomarker as a surrogate marker for disease progression in breast canc

    SBC: A&G PHARMACEUTICAL, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): 40,000 women die annually in the US as a result of breast cancer (BC). Although BC can be controlled if detected early, a significant number is not detected until later and these patients are treated using therapies tocontrol both primary tumor and micro-metastatic disease. Therapy response is monitored using imaging and clinical assessment. Failure to detect e ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  4. Protease chain reactions for molecular analysis of cancer markers

    SBC: POTOMAC AFFINITY PROTEIN LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Our objective is to develop a protease chain reaction technology (ProCR) which will enable ultra- sensitive molecular detection. A protease chain reaction has four basic components: 1) a protease conjugated to a bindingmolecule, 2) an unconjugated protease, 3) an inhibitor protein which contains a proteolytic cleavage site and 4) a protease substrate which gene ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  5. Physics-Based Head and Neck Surgical Simulation of Soft Tissue Manipulation

    SBC: SIMQUEST INTERNATIONAL, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): SimQuest LLC proposes to develop a physics-based head and neck simulator to enhance training of dental, endodontic, oral, maxillofacial, plastic, trauma, ENT, and other trainees and surgical educators. This Phase I workwill advance the state of the science in surgical education by establishing the foundation for a simulator that will greatly enhance surgical tr ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  6. Ultrathin Intraoral 3D Camera

    SBC: XIGEN, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Intraoral three-dimensional (3D) imaging capability promises to revolutionize traditional dental practice workflow by allowing chairside real-time 3D digital model acquisition without taking traditional impressions, thus facilitating speedy and accurate computer-aided-design (CAD) and computer-aided- manufacturing (CAM) of dental restorations at dentist's ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  7. Oral care treatment for mobility-impaired patients

    SBC: Athena Environmental Sciences Inc            Topic: NIDCR

    DESCRIPTION (provided by applicant): Biofilm infections are a major cause of mortality and morbidity. Dental caries occur as a result of an infectious disease in the oral cavity that is characterized by localized demineralization of susceptible tooth surfaces. The onset of dental caries results from the formation of an oral biofilm or plaque. Oral biofilm build-up is prevented using mechanical (b ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  8. Feasibibility of deep hypothermic (18-22C) perfusion storage of livers for transp

    SBC: Cell & Tissue Systems, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): More than 43,000 Americans die each year from liver disease, making it the 10th leading disease- related cause of death in the US. Cirrhosis with irreversible injury and scarring of the liver is the most prevalent causeof liver failure and is attributable to alcohol abuse as well as hepatitis. Although alcohol has been the primary cause of cirrhosis, the Center ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  9. Pancreas perfusion with PFC-Unisol

    SBC: Cell & Tissue Systems, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): There is a worldwide consensus that islet transplantation may be considered a viable option for the treatment of insulin-dependent diabetes mellitus, and clinical trials are underway at many centers around the world. Asthis approach for curing diabetes transitions into a routine clinical standard of care so the demand for donor islets will escalate. Moreover, t ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  10. Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites

    SBC: CarboNix LLC            Topic: NIEHS

    DESCRIPTION (provided by applicant): Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induceasthma, especially in children. The focus of this project is on the dust mite. Carbonix LLC proposes a Phase I research program, leading to a com ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
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