Award Data

Next generation network applications will require high, dynamically-stable transport throughputs at the application level, in order to support such tasks as computational monitoring and steering on supercomputers, massive wide-area data transfers between storage systems, and remote instrument control. However, the current shared IP infrastructure is unsuited for providing the unimpeded stable ban ...

DESCRIPTION (provided by applicant): Biologically and clinically relevant proteomics data can only be generated if organ or tissue samples investigated consist of homogeneous cell populations, in which no unwanted cells of different types and/or developmen t stages obscure the results. Thus, several tissue microdissection technologies have been developed to provide a rapid and straightforward meth ...

DESCRIPTION (provided by applicant): Web-Based Wellness Policy Toolkit for Obesity Prevention in Middle Schools The childhood obesity epidemic is escalating with significant adverse health and economic impact. We propose to develop and test a web-based too lkit designed to facilitate implementation of required wellness policies (WP) in middle schools as well as a commercialization strategy for und ...

DESCRIPTION (provided by applicant): Our overall goal is to develop a novel computing solution for automatic and accurate registration (spatial alignment) of three-dimensional (3D) medical images of any modality and any anatomy (rigid or deformable) in 1 m inute. Such capability currently does not exist. Existing image registration solutions have limited accuracy and/or limited applicability, prev ...

DESCRIPTION (provided by applicant): The goal of the proposed work is development of sensitive diagnostic serological assay panels for detection of hepatocellular carcinoma (HCC). Currently, the only biomarker used in HCC diagnosis is the measurement of al pha feto protein (AFP) in patient serum, which exhibits poor sensitivity and specificity. There is a need for alternative biomarkers to more ef ...

DESCRIPTION (provided by applicant): This Small Business Technology Transfer (STTR) proposal responds to program announcement PAS-06-131 entitled, Applications of Imaging and Sensor Technologies for Clinical Aging Research . The purpose of the announcemen t is to improve imaging methods for measuring age-related changes in regulation of complex physiologic systems, including responses to stimuli ...

The Department of Energy¿s large research facilities need improved neutron detectors for thermal neutron instrumentation. Where large detector arrays are needed, single-wire overpressured 3He tube detectors are the detector of choice, because they are so cost effective. Though useful, current detectors do not meet the demands of current high intensity neutron sources, such as the Spallation N ...

DESCRIPTION (provided by applicant): PharmacoPhotonics, LLC proposes research leading to a novel 2-photon in vivo fluorescence method for monitoring glomerular filtration rate (GFR) in acute kidney injury (AKI). AKI remains a vexing clinical problem result ing in unacceptably high patient mortality, development of chronic kidney disease and enhanced progression to end stage renal disease. Although ...

DESCRIPTION (provided by applicant): A significant problem currently hindering proteomics studies is the identification of peptides and proteins from mass spectral data. This problem is manifest in the difficulty to establish confidence limits of protein a nd peptide identifications. A serious concern is the tendency for the occurrence of false positive assignments. The development of an integrate ...

DESCRIPTION (provided by applicant): Traditional methods for training clinicians and students in mental health disciplines in substance abuse assessment have been restricted to role-playing, mock interviews, textbook lessons, and video instruction. All of these tools have limitations for imparting real world experiences. Specifically, traditional methods of instruction do not include realistic in ...