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DESCRIPTION provided by applicant Metastasis or dissemination of primary tumor cells is the major cause of mortality in cancer patients Circulating tumor cells CTCs in the bloodstream are key players in the establishment of metastatic tumors Recent studies demonstrated that the number of CTCs present in patient blood directly correlate with cancer progression recurrence and survival rate ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Corneal clouding caused by failure of the corneal endothelial deturgesence mechanism affects over million people in the US and well over million people worldwide It is the most common corneal disease and is historically a common cause of blindness Surgical treatment by corneal grafting has been successful when available but is limited by the availabili ...

DESCRIPTION provided by applicant Mass spectrometry based proteomics is an emerging technology that has seen possible applications everywhere The technique can potentially use one drop of our blood to reveal onset and progress of diseases Current Randamp D using plasma serum proteome sample sets however is severely limited by the high complexity and dynamic range of protein concentrations ...

DESCRIPTION provided by applicant The measurement monitoring and use of bioelectric signals has evolved from the measurement of the electrical activity of the heart to encompass tissues ranging from cardiac skeletal and smooth muscles to brain and peripheral nerve tissues Together with this development has been the evolution of specialized equipment to capture and interpret these minute sig ...

MapReduce is a very popular data analytic framework that is widely used in both industry and scientific research. Despite the popularity of MapReduce, there are several obstacles to applying it for developing some commercial and scientific data analysis applications. The project will develop a Native data FOrmat MapREDuce-like framework, iNFORMER, based on OSUs SciMate architecture. The framework ...

For advanced gas turbines where turbine inlet temperature reaches 2650F and beyond, the current state-of-the-art thermal barrier coating (TBC) systems are not adequate to provide the needed protection for the metallic components of the turbine engine. Thus there is a need to develop new chemistries and architectures for TBC systems (both bond coats and top TBCs) with enhanced durability. For the ...

Current ground penetrating radar based root analysis techniques have been mainly targeted for coarse root analysis. In order to extend the GPR technology to fine root analysis, it is necessary to design an unconventional GPR system that provides root information in the entire area under observation with greater accuracy and penetration depth. Specialized signal/image processing algorithms applicab ...

At present, CdZnTe is considered the material of choice for efficient, room temperature gamma-radiation detection systems used for the detection and identification of radionuclides. Despite the advances in CdZnTe materials technology during the last decade, the major impediments in the progress of - ray detection technology are the low yield of device quality materials and detectors, and the limit ...

There is an acute need for low-power, low-cost, portable mid-wave infrared (MWIR) thermal imaging systems. Current HgCdTe focal plane array (FPA) detectors have high fabrication cost and require low operating temperature. Recent advances in quantum dot (Q