Award Data

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Ebola and Marburg viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as the biosafety level agents Currently there is no effective vaccine or therapeutic treatment against filoviral i ...

DESCRIPTION provided by applicant Lassa fever virus LASV and Machupo virus MACV are hemorrhagic fever arenaviruses which are classified as Category A Agents Currently there are no licensed LASV or MACV vaccines and LASV MACV therapy is limited to use of the nucleoside analog ribavirin which is only partially effective and associated with significant side effects The impact of arenavirus ...

DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

To achieve the goals of this program improving spectral coverage and output power of monolithic QCL sources as well as the development of a production and manufacturing plan - we propose to develop in collaboration with MIT Lincoln Laboratory a broadly tunable high power source that is based on Eos"proprietary QCL array technology. The current generation of Eos"commercially available fully packag ...

This STTR project seeks to overcome the performance limitations of experimental sulfur tolerant SOFC materials by combining two elements of efficient SOFC design: 1) micro-tubular arrays (OD

The Department of Defense is concerned with circadian rhythm misalignments as they are known to affect judgment, psychomotor skills, and can lead to Post-Traumatic Stress Disorder (PTSD). At present, there is no comprehensive unobtrusive and easy-to-use solution that measures the circadian misalignment and automatically administers the appropriate therapy for realignment of circadian rhythm. Intel ...

Antimicrobial treatment of military textile systems is intended to provide enhanced protection to the Warfighter in the field by preventing colonization of harmful bacteria that cause problems such as odor, dermatitis, and skin irritation. Current treatments can impart antimicrobial functionality to textiles; however, they all possess broad-spectrum antimicrobial activity, affecting all skin bacte ...

In this STTR program, technology created at the University of California at Santa Barbara (UCSB) to fabricate silicon photonics based integrated laser devices, including wafer bonded gain elements, will be utilized to develop ultra-coherent integrated laser devices that are widely tunable. Novel laser designs developed by Morton Photonics, taking advantage of ultra-low loss microresonator based f ...