Award Data

PROJECT SUMMARY Aminoglycosides are one of the cheapest and well known antibiotics in clinical use for over years but one of the major limitations in their use is their ototoxicity We are developing fast and low cost methods to develop aminoglycosides with anti ribosomal activities and reduced toxicity In this project we will identify novel aminoglycoside antibacterials that show reduced ...

DESCRIPTION provided by applicant Nucleic acids are avenues for drug design both as therapeutics and as targets Here we propose to establish new methods for identifying antibiotic ribosome targets and lead compounds Targeting specific RNA such as rRNA which are involved in proliferation and survival of bacteria is a promising approach We are developing fast and low cost methods to screen s ...

DESCRIPTION provided by applicant The title of this project is andquot Treating Collagen induced Arthritis with Fc Receptor Activating Nanoparticlesandquot We and others have identified and characterized a population of macrophages with potent immunorergulatory activity The goal of the present proposal is to induce the production of regulatory macrophages R M in mice and determine wheth ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

The Department of Defense is concerned about adverse effects of circadian rhythm misalignment on sleep hygiene and well-being of service members and veterans who suffer from symptoms of Post-Traumatic Stress Disorder (PTSD). Intelligent Automation, Inc., University of Central Florida RESTORES center and consultants from Lighting Research Center at Rensselaer Polytechnic Institute, propose to devel ...

To protect national interests and effectively plan, coordinate and execute military operations, support training and foster partnerships, the U.S. military must better understand populations involved in or impacted by operations. The successful population data analysis is critical in several aspects including but not limited to: assessment of progress towards tactical, operational and strategical ...

The meteoric rise of personally identifying information (PII) created and shared online is unprecedented. The sheer volume of open source intelligence available on sites such Facebook, Twitter, LinkedIn, message forums, Instagram, etc. makes the task of collecting and organizing OSINT increasingly laborious for analysts. Zeuss has already built and tested an operational product that addresses this ...

Wireless communication systems are critical components of Department of Defense (DoD) information operations, such as tactical mobile ad hoc networks (MANETs) and control of unmanned vehicles. These systems must offer trusted and reliable mission-oriented information exchange over the air in contested, congested, and adversary battlefield scenarios. The broadcast nature of the wireless communicati ...

NadirSAR imaging offers a means to detect targets in challenging environments. TSC and SDL propose to leverage the work we have already performed for RRTO to develop and demonstrate a NadirSAR imaging technique at X-band. TSCs baseline technique exploits range resolution for height and performs SAR Tomographic processing around a circular flight path to obtain resolution in the ground plane. Measu ...

DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...