Award Data

PROJECT SUMMARYAminoglycosides are one of the cheapest and well known antibiotics in clinical use for overyearsbut one of the major limitations in their use is their ototoxicityWe are developing fast and low cost methods to develop aminoglycosides with antiribosomal activities and reduced toxicityIn this projectwe will identify novel aminoglycoside antibacterialsthat show reduced ototoxicityComple ...

Autism spectrum disorderASDis a neurodevelopmental disorder characterized by significant deficits in reciprocal social interactionsimpaired communication and restrictedrepetitive behaviorswith a prevalence ofinchildren in the USEarly intervention programs have been shown to be effective for improving IQlanguageand social skills for toddlers as young asmonths of ageDiagnosis of ASD is currently bas ...

PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

This STTR project seeks to overcome the performance limitations of experimental sulfur tolerant SOFC materials by combining two elements of efficient SOFC design: 1) micro-tubular arrays (OD

The Department of Defense is concerned with circadian rhythm misalignments as they are known to affect judgment, psychomotor skills, and can lead to Post-Traumatic Stress Disorder (PTSD). At present, there is no comprehensive unobtrusive and easy-to-use solution that measures the circadian misalignment and automatically administers the appropriate therapy for realignment of circadian rhythm. Intel ...

In this STTR program, technology created at the University of California at Santa Barbara (UCSB) to fabricate silicon photonics based integrated laser devices, including wafer bonded gain elements, will be utilized to develop ultra-coherent integrated laser devices that are widely tunable. Novel laser designs developed by Morton Photonics, taking advantage of ultra-low loss microresonator based f ...

The proposed project will demonstrate high-frequency (0.5 5 GHz) operation of novel 2-dimensional semiconductor molybdinum disulphide (MoS2) based field-effect transistors. Our project will focus on innovative growth startegies for large-area growth of MoS2 along with novel device design methodologies which will consider the tradeoffs between monolayer and multilayer device designs for high-frequ ...