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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. GalT-KO Pigs Expressing Primate CD47 to Facilitate Organ Xenografts

    SBC: MINITUBE OF AMERICA            Topic: NIAID

    DESCRIPTION (provided by applicant): Xenotransplantation with pig organs offers the best near term hope for satisfying the limitation imposed by shortage of human organs. Although hyperacute rejection of pig organs in primate recipients has been overcome by the production of (-1,3-galactosyltransferase knockout (GalT-KO) pigs, experiments to date with GalT-KO organs strongly suggest that clinical ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a Peptidomic Rapid Point-of-Care TB Diagnostic

    SBC: NEW YORK UNIVERSITY            Topic: NIAID

    DESCRIPTION (provided by applicant): The goals of this proposal are to devise rapid serological tests that can replace the sputum smear test for the diagnosis of active TB and meets the WHO specifications to replace microscopy in resource-limited countries based on immunodominant peptides from three M. tb cell-wall proteins. Although direct smear microscopy is highly specific, the test is tedious, ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  3. Cotton Rat: Animal Model Predictive of Clinical Responses to HSV Vaccines

    SBC: VIRION SYSTEMS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Genital herpes is one of the most prevalent sexually transmitted infections worldwide and is associated with substantial morbidity. The impact of genital herpes as a public health threat is amplified because of its epidemiologic synergy with HIV. Epidemiological studies consistently demonstrate that HSV infection increases the risk of HIV transmission and acqu ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  4. Early detection of prostate cancer in urine

    SBC: New Horizons Diagnostics            Topic: NCI

    DESCRIPTION (provided by applicant): Prostate cancer is the second most common cancer in men, and the second leading cause of cancer death. However, when prostate cancer is diagnosed in its early stages, it can be effectively treated and cured. Combined with the digital rectal examination, the prostate specific antigen (PSA) test has been widely used to detect prostate cancer in its early stages. ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Improving liver lesion biopsy in the CT suite through fusion with PET images

    SBC: KITWARE INC            Topic: NCI

    DESCRIPTION (provided by applicant): The broad objective of this proposal is to improve the clinical effectiveness of liver lesion biopsy by fusing respiratory-compensated PET with CT images in the CT suite. On CT imaging alone, localization of liver lesions can potentially be challenging, particularly in selected cases where differentiation of the tumor from adjacent liver parenchyma may be diffi ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  6. MDC-1231 for cancer prevention

    SBC: Medicon            Topic: NCI

    DESCRIPTION (provided by applicant): Strong evidence supports the notion that chemoprevention has the potential to be a major component of colorectal cancer control. The prevention of cancer depends heavily on the development of safe and effective agents. NSAIDs prevent colorectal cancer but have two major limitations that preclude their large-scale application to prevent colorectal cancer: a) sig ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  7. Enabling high dose regional chemotherapy while minimizing systemic toxicity

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NCI

    DESCRIPTION (provided by applicant): Enabling high dose regional chemotherapy with minimal systemic toxicity Abstract: The primary objective of this proposed study is to develop a filtration system that maximizes the removal (gt90%) of chemotherapeutic agents, such as doxorubicin, from blood while minimizing adverse effects of filtration on blood chemistry and hematological parameters. Vascular V ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  8. Innovative Computer Prototype for HIV Screening and Brief Intervention

    SBC: RESEARCH CIRCLE ASSOCIATES            Topic: NIDA

    DESCRIPTION (provided by applicant): HIV continues to be a major public health problem in the United States, but there has been limited penetration of HIV prevention services in many healthcare settings. Novel methods for seamlessly integrating HIV prevention into medical practice are needed. The proposed Phase 1 STTR project seeks to establish the feasibility of designing key components of an inn ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. Lentiviral gene therapy for mucopolysaccharidosis

    SBC: LENTIGEN CORPORATION            Topic: NIDDK

    DESCRIPTION (provided by applicant): Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is an X-linked recessive inherited disorder caused by absence of iduronate-2-sulfatase, resulting in systemic accumulation of glycosaminoglycans heparan sulphate and dermatan sulphate. Affected individuals suffer from skeletal abnormalities, organomegaly, life- threatening obstructive airway disease, and, ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  10. Web-Based Infrastructure for Comparison and Validation of Image Computing Methods

    SBC: KITWARE INC            Topic: NIBIB

    DESCRIPTION (provided by applicant): Validation of computing algorithms has been a challenging topic over the last few years. In fact, several international workshops in the medical imaging field started to involve the community through grand challenges . A grand challenge involves selecting driving biological/scientific problem and asking experts to submit their best results and methods to solve ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
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