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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel Inhibitors of Pim Protein Kinases

    SBC: VORTEX BIOTECHNOLOGY CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): There is a growing body of evidence that implicates the protein kinase Pim-1 as a major driver of prostate cancer progression, and perhaps response to chemotherapy. Pim-1 is overexpressed in early prostate intraepithelial neoplasia and metastatic prostate cancer, and its levels predict response to therapy. Pim-1-overexpressing mouse prostate stem cells demonstr ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  2. Electronic Image Trial Management System

    SBC: VIRTUALSCOPICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Delays in FDA drug approval are measured in lost lives (estimated to be hundreds of thousands over the last few decades) and increased costs to U.S. citizens for drugs that are eventually approved. One factor contributing to the delay in drug approvals is the widespread use of time-consuming and error-prone manual methods to deliver medical images (i.e. CT, MR, ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  3. Cardiac Regenerative Therapy with Cyclin A2

    SBC: VentriNova, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The morbidity and mortality due to cardiovascular disease is attributed to the lack of significant replicative potential of adult mammalian cardiomyocytes. Thus myocyte loss in response to ischemic injury typically results in scar formation and a decline of cardiac function that is usually irreversible. The cessation of myocyte proliferation is associated with ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  4. Tooth Phone Auditory Device TPAD

    SBC: Audiodontics LLC            Topic: N/A

    DESCRIPTION (provided by applicant): TOPIC - Tooth Phone(R) Auditory Device - TPAD ABSTRACT The Tooth Phone(R) Auditory Device - TPAD is new alternative device to the only direct bone conduction hearing aid currently accepted by the Food and Drug Administration (FDA) for the treatment of certain specific types of hearing loss. Unlike the precedent FDA approved device that uses an osseointegrated i ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  5. Acid Ceramidase, Target for Cancer

    SBC: Sphingogene, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Acid ceramidase (AC) has been implicated as a novel target for cancer therapy because of its pivotal role in regulating interconversion of three key bioactive lipids; ceramide (Cer), sphingosine (Sph) and Sphingosine-1-Phosphate (S1P). It is well known that Cer functions predominantly as a tumor suppressor lipid and mediator of apoptosis following chemo and rad ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  6. New chaperones for folding and assembly of proteins

    SBC: FIDELITY SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): A novel approach is needed to overcome the deficiencies of protein production technology and ensure the produced enzymes fold into physiologically effective three-dimensional conformations. We discovered that incorporation of novel archaeal chaperones into a host-vector system and into in vitro enzymatic reactions helps both to recover proteins from inclusion b ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  7. Data acquisition system for multiplex analysis of color encoded particles

    SBC: ADVANCED BIOMEDICAL MACHINES INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The main goal of this project is a development of the high throughput data acquisition system based on single photon spectrometer which enables detection and highly accurate recognition of sets containing millions of stochastically encoded microparticles and the validation of this system using genome-wide copy number analysis as a model system. As an outcome of ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  8. Advanced Software for Enabling Quantitative 3D Stress Echocardiography

    SBC: IGI TECHNOLOGIES, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Through more than 5 years of research, we have developed a new cardiovascular procedure termed quantitative three-dimensional (3D) stress echocardiography (echo). Because of exceedingly high computational demands, the procedure remains clinically nonviable despite our mature academic research. The objective of this STTR project is to remove the computation bott ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  9. Family Education for Confirmed Newborn Screen

    SBC: FULL CIRCLE STUDIOS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Newborn screening (NBS) is a national public health initiative directed at identifying genetic or metabolic disorders in newborns which, if left untreated, are associated with significant morbidity or mortality. The role and scope of NBS is rapidly expanding given technological advances. Concurrent with this expansion is a widening gap in educational, emotional ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a highly efficient sperm freeze drying system

    SBC: MILLROCK TECHNOLOGY, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objective of this STTR Phase I application is to test the feasibility of designing and developing a high-throughput, user-friendly, and reliable freeze-drying system that is customized and scaleable for the preservation of mouse sperm. The Aims of the project are to define the specifications and characteristics of a novel freeze-drying system, des ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
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