Award Data

DESCRIPTION (provided by applicant): One of the largest bottlenecks in high-throughput protein structure determination (structural genomics) and in subsequent drug targeting (pharmocogenomics) is the acquisition of soluble correctly folded functional protein products. Unfortunately, a large amount of the protein expression systems that are commonly used yield insoluble or soluble misfolded protein ...

DESCRIPTION (provided by applicant): The indications for androgen therapy has expanded such that today, androgens are used in both men and women, and in addition to their use in treating primary (or secondary) hypogonadism the potential benefit of increasing bone mineral density, inducing greater muscle mass and strength, enhancing sexual function, and improving mood. Androgens are also being cons ...

DESCRIPTION (provided by applicant): One of the primary and disabling clinical manifestations of Parkinson's disease (PD) is locomotor dysfunction, such as small, variable stride length and freezing of gait. Treatment of PD to a large extent focuses on replacing depleted dopamine at the striatum to maintain mobility for as long as possible. Clinical assessment relies on brief observation and frequ ...

DESCRIPTION (provided by applicant): It is anticipated that only a third of today's high school students will go onto college despite consistent data that support the benefit of post-secondary education for individuals. Concurrently, daily Internet use among adolescents is nearing the fifty-percent mark, with broadband Internet steadily growing toward ubiquity. This project aims to leverage the ma ...

DESCRIPTION (provided by applicant): Our long term goal is to develop cellular based immunotherapy for the treatment of malignancy. One approach to enhancing the effects of cellular immunotherapy is via gene therapy. We are currently focused on enhancing the antitumor effects of adoptive T cell therapy using lentiviral vector-mediated genetic modification of cells to express a universal T cell rec ...

DESCRIPTION (provided by applicant): The overall goal of this project is to develop a biologic therapeutic to treat systemic inflammatory response syndrome (SIRS) using a novel human recombinant lactoferrin that contains "humanized" glycosylation patterns. SIRS is a clinical expression of the action of complex acute-phase intrinsic mediators that precedes sepsis and subsequent tissue damage leadi ...

DESCRIPTION (provided by applicant): There is a crucial need for increases in resources and manpower in research in kidney disease. Probetex was founded as a "Renal Research Resource Company" to create a repository of "off the-shelf" tissue products to provide readily available samples and help investigators to quickly and efficiently explore their ideas on established and standardized models or i ...

DESCRIPTION (provided by applicant): The overall goal of this Phase I STTR project is to establish the technical merit and feasibility of producing a web-based multimedia intervention program for adolescents and young adults with familial adenomatous polyposis (FAP), an inherited colorectal cancer syndrome. Our long-term goal is to develop and evaluate an intervention that will provide information ...

DESCRIPTION (provided by applicant): Currently up to 50% of HIV infected individuals including those taking antiretroviral therapy have mild neurocognitive disorder. Furthermore, the population living with HIV infection continues to grow and there are now over one million people living with HIV in the US and 42 million around the world. This indicates that persistent HIV associated cognitive impai ...

DESCRIPTION (provided by applicant): Bacterial contamination of Dental water lines is a major concern in modern Dentistry and may cause infection in Dental patients with compromised immune systems. This includes patients with cancer, diabetes, or AIDS; cardiac patients who often require prophylactic antibiotics prior to Dental treatment; the elderly, young children, and pregnant women. Bacterial l ...