Award Data

DESCRIPTION (provided by applicant): Tumor markers, measured in peripheral blood, could assist in diagnosis and management of non-small cell lung cancer (NSCLC) and potentially improve historically dismal outcomes. Circulating antibodies, generated to a wide range of tumor-associated proteins, can be translated into a valuable blood test for lung cancer. Preliminary data supports this hypothesis. ...

DESCRIPTION (provided by applicant): The trigger for autoimmune destruction of pancreatic beta cells in Type 1 diabetes (T1D) is unclear. Evidence exists for the role of increased intestinal permeability, secondary to intestinal tight junctions (tj) disassembly, in the pathogenesis of various autoimmune diseases including T1 D. Over the last decade our studies have focused on the mechanism(s) of a ...

DESCRIPTION (provided by applicant): Because of the long history of the use of formalin as the standard fixative for tissue processing in histopathology, there are a large number of archival formalin-fixed and paraffin-embedded (FFPE) tissue banks worldwide. These FFPE tissue collections, with the attached clinical and outcome information, present invaluable resources for conducting retrospective ...

DESCRIPTION (provided by applicant): The wound repair process in skin is initiated immediately after an injury and induces a cascade of events including inflammation, proliferation, and scar production/tissue remodeling. One of the common complications of wound healing is excessive scarring, leading to undesirable changes in skin mechanical function, as well as cosmetic disfiguration. The adverse ...

DESCRIPTION (provided by applicant): Adherence to HIV antiretroviral therapy (ART) is closely associated with viral suppression, drug resistance and disease progression. Although near perfect adherence is needed for reliable viral suppression, average adherence to HIV antiretroviral therapy is under 70%. Accurate assessment of adherence is the first step in improving adherence because it identifie ...

DESCRIPTION (provided by applicant): The goal of the proposed project is to generate the pre-clinical data necessary to provide proof-of-principle for future clinical studies of pro-apoptotic lentiviral vector (LV) gene therapy using small hairpin RNA (shRNA) to target ?HIV-Associated Life Preserver? (HALP) and ring finger protein 7 (RNF7), two of the crucial anti- apoptotic genes in acquired HIV ...

DESCRIPTION (provided by applicant): The proposed collaborative project assesses the feasibility of integrating a new software module designed to collect, interpret, and manage family history into electronic health record (EHR) systems in a manner that is useful and acceptable to primary care providers and patients. The final product to be developed will be a commercially viable software module ca ...

DESCRIPTION (provided by applicant): Alcohol use disorders are common among primary care patients. They are also associated with serious adverse effects. Many health care professionals, however, often lack sufficient background in alcohol screening and brief intervention strategies to effectively help patients who use alcohol above recommended limits. In particular, they often lack the necessary i ...

DESCRIPTION (provided by applicant): Genital herpes is one of the most prevalent sexually transmitted infections (STI) worldwide and is associated with substantial morbidity. The impact of genital herpes as a public health threat is amplified because of its epidemiologic synergy with HIV. Epidemiological studies consistently demonstrate that genital herpes infection increases the risk of HIV trans ...

DESCRIPTION (provided by applicant): Harmful Algal Blooms, or "HAB's", are linked to many cases of human poisoning each year. Economic losses and costs to the fishing industry, public health, and tourism are estimated to be $40,000,000 annually, as of the late 1990s. One such HAB causes paralytic shellfish poisoning (PSP). Following an algal bloom, the toxins released by the microbes may accumulat ...