Award Data

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Ovarian cancer is the fifth most leading cause of cancer related deaths in women in the US It has been observed that the cancer relapses within relatively short periods of time even after the surgery and chemotherapy Therefore immunotherapeutic strategies may serve as an alternative to control the recurrence or progression of ovarian cancer Oral vaccines ar ...

DESCRIPTION provided by applicant Intracerebral hemorrhage ICH is a major public health problem with highest mortality rate of all stroke subtypes and long term disability Since there are no available FDA approved therapies for ICH it is of enormous importance to establish effective treatment for this medical condition Following ICH the deposited blood is damaging initially via compression ...

There is an ongoing effort to replace high activity radioactive sources that could pose a risk for use as terrorist weapons with non-radioisotope based technologies. Currently radioactive sources serve a number of critical needs including the treatment and diagnosis of disease, inspection and certification of critical mechanical structures, the sterilization of food and medical products, ...

At present, CdZnTe is considered the material of choice for efficient, room temperature gamma-radiation detection systems used for the detection and identification of radionuclides. Despite the advances in CdZnTe materials technology during the last decade, the major impediments in the progress of - ray detection technology are the low yield of device quality materials and detectors, and the limit ...

76164-The economical production of natural gas from conventional and low permeability gas resources requires additional advances in exploration and production technologies. In particular, diagnostic and imaging technologies are needed to assess the effectiveness of new extraction techniques related to drilling, completion, and stimulation. This project will develop three-dimensional, multicompon ...

72323- The exploration of certain regimes of high energy physics will require the development of photocathodes with emitted electron spin-polarizations above 90%. Emitted electron spin-polarizations approaching 90% have been achieved, but at the expense of quantum yield. Because natural diffusion spatial spread disfavors complete transport to the emitting surface, this project will develop tec ...

75742-Lighting is the largest component of worldwide energy usage, consuming 20% of the total electricity. Polymer-based Organic Light Emitting Diodes (OLED) has been recognized as an ideal source for area lighting applications due to its potential for large area production, high efficiency and unit brightness, and color rendering effects. However, in order to achieve low cost and high efficienc ...

75866-The difficult problems being tackled in the accelerator community are those that are nonlinear, substantially unmodeled, and vary over time. These problems would be ideal candidates for model-based optimization and control if representative models could be developed. Such models must be inexpensive to deploy and maintain, and must remain valid throughout the operating region of the system ...

75707-Using current technology, oil and gas in the subsurface cannot be reliably predicted from seismic data. As a result, some domestic oil and gas fields go undiscovered and unexploited, thereby increasing the Nation¿s need to import energy. This project will develop a new class of seismic methods based on inelastic rock properties (attenuation) that will provide a much better link between ...