Award Data

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Ovarian cancer is the fifth most leading cause of cancer related deaths in women in the US It has been observed that the cancer relapses within relatively short periods of time even after the surgery and chemotherapy Therefore immunotherapeutic strategies may serve as an alternative to control the recurrence or progression of ovarian cancer Oral vaccines ar ...

DESCRIPTION provided by applicant Intracerebral hemorrhage ICH is a major public health problem with highest mortality rate of all stroke subtypes and long term disability Since there are no available FDA approved therapies for ICH it is of enormous importance to establish effective treatment for this medical condition Following ICH the deposited blood is damaging initially via compression ...

There is an ongoing effort to replace high activity radioactive sources that could pose a risk for use as terrorist weapons with non-radioisotope based technologies. Currently radioactive sources serve a number of critical needs including the treatment and diagnosis of disease, inspection and certification of critical mechanical structures, the sterilization of food and medical products, ...

At present, CdZnTe is considered the material of choice for efficient, room temperature gamma-radiation detection systems used for the detection and identification of radionuclides. Despite the advances in CdZnTe materials technology during the last decade, the major impediments in the progress of - ray detection technology are the low yield of device quality materials and detectors, and the limit ...

While there is no lack of performance counter tools for coarse-grained measurement of cache activity, there is a critical lack of tools for relating data layout to cache behavior to application performance. Generally, any nontrivial optimizations are either not done at all, or are done by hand requiring significant time and expertise. To the best of our knowledge no tool available to users measure ...

Selection of the Plasma-Facing Component (PFC) material composition is a primary consideration in future fusion reactor design. The PFC materials must not only withstand the harsh operating conditions of the reactor, but the amount of tritium uptake experienced by the PFC during operation is a significant factor. Proper operation, safety and environmental impact mandate that t ...

The ultimate goal of the project is to demonstrate that the rotating liner engine (RLE) can increase fuel efficiency in heavy duty vehicles by about 3.5-4% at full load, about 25% at idle, and about 10% for an average duty cycle, can reduce CO2, NOx and PM and reduce engine wear. Design already completed. The face seal is the only technical challenge of the concept, and the main design features pe ...

Solar water heaters are a well-established renewable energy technology that has been widely adopted outside of the United States. Here we propose to significantly improve the evacuated solar tube collectors (ETC) by utilizing the dry-drawable carbon nanotube (CNT) sheets for solar energy absorption and CNT multifunctional nanocomposites with functional layers of heat accumulators and heat transpo ...

A significant portion of the waste heat from engine exhaust can be recovered using thermoelectric generators to achieve up to 10% gain in automotive mileage. There have been several efforts underway on this front but most have focused on demonstrating thermoelectric generators using bulk materials that consume significant amount of raw materials and are prone to failures due to thermal expansion, ...