Award Data

DESCRIPTION provided by applicant Seasonal influenza flu virus an NIAID category C priority pathogen causes widespread infection resulting in at least million cases of severe illness and deaths worldwide Young children and elderly or immunocompromised individuals are typically at greater risk of severe illness or death from influenza Newly emerging strains can result ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

The US Navy faces daunting energy challenges that will further increase in severity, given the ever-increasing global demand for energy, diminishing energy supplies and demand for enhanced environmental stewardship. Navys environment foot print consists of both emissions and noise generated every day around the world. Additionally, noise is an important issue for the Navy due to the adverse effect ...

A general framework for course of action (COA) recommender systems consists of four primary functional areas : (1) mapping human entered COA into formalized, machine readable knowledge representation; (2) deconstructing COA decision models into relevant features or variables of interest; (3) gathering and routing intelligence related to those features to specific warfighters evaluating COA; and (4 ...

The goal of this project is to develop processing capabilities for high-strength and ultra-conductive wires to improve power-to-weight ratios and energy efficiency of electrical military systems. The first objective of this Phase I project is to build up quantitative microstructure-property models to guide the development of electrical and thermal conductive carbon nanotubes (CNTs) modified coppe ...

ABSTRACT: The ability to obtain time-resolved, direct wall shear stress measurement is an important asset to aerodynamic research, flow control and to enhance the fundamental understanding of the turbulent boundary layer. Due to a lack of reliable and affordable skin friction sensors, existing indirect methods are used to measure wall shear stress but their usefulness is limited since prior kno ...

3D printed phased array antennas (PAA) would be more rugged, lighter and take a variety of shapes and including unmanned aerial vehicle (UAV) wings. Printing antennas, passives and interconnects has been demonstrated in 3D printing. Using printed electronic approaches for printing Field Effect Transistors (FET) has been demonstrated and including printing switches in the GHz regime. The challenge ...

Pharad is teaming with the Applied Physics Laboratory of The Johns Hopkins University to propose and investigate the feasibility of wideband (VHF to SHF) RF-to-digital photonic link architectures with real-time digital signal processing (DSP) that can meet the stringent performance metrics of military systems. The key requirements for our wideband DSP linearized RF-to-digital photonic link include ...