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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Nucleobase aminosugars with reduced ototoxicity

    SBC: NUBAD LLC            Topic: Y

    PROJECT SUMMARYAminoglycosides are one of the cheapest and well known antibiotics in clinical use for overyearsbut one of the major limitations in their use is their ototoxicityWe are developing fast and low cost methods to develop aminoglycosides with antiribosomal activities and reduced toxicityIn this projectwe will identify novel aminoglycoside antibacterialsthat show reduced ototoxicityComple ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Development of an Autism Spectrum Disorder Screening Test based upon Metabolic Profiling of Fresh Blood Samples

    SBC: CIRCA BIOSCIENCE LLC            Topic: 102

    Autism spectrum disorderASDis a neurodevelopmental disorder characterized by significant deficits in reciprocal social interactionsimpaired communication and restrictedrepetitive behaviorswith a prevalence ofinchildren in the USEarly intervention programs have been shown to be effective for improving IQlanguageand social skills for toddlers as young asmonths of ageDiagnosis of ASD is currently bas ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. CCN3-derrived peptides to treat liver injury

    SBC: BLR Bio            Topic: 200

    Project Summary Chronic liver disease is becoming a major public health issue with estimates of up to 40% prevalence of non- alcoholic fatty liver disease (NAFLD) and 12% with non-alcoholic steatohepatitis (NASH) in the U.S. Liver disease and cirrhosis was the 12th leading cause of mortality in the U.S. in 2014. Obesity and metabolic syndrome are important causes of fatty liver disease or steatosi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Building an evidentiary case for circulating GHBP as a biomarker for drug-associated stunting of growth

    SBC: REVERAGEN BIOPHARMA, INC.            Topic: NICHD

    There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Commercialization of a Rapid Blood Test for Traumatic Brain Injury

    SBC: Fawkes Biotechnology, LLC            Topic: 100

    Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Quantitative Magnetic Resonance Imaging Phantoms

    SBC: CALIMETRIX LLC            Topic: NIBIB

    PROJECT SUMMARYThe overall goal of this Phase I proposal is to designdevelop and test the feasibility of advanced quantitative magnetic resonance imagingMRIphantoms that mimic the simultaneous presence of fatiron and fibrosisFatiron and fibrosis are three principal histological coexisting features of many important disease statesPhantoms are highly controlled test objects that accurately reflect t ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Noninvasive Seizure Screening in Preclinical Models of Epilepsy

    SBC: SIGNAL SOLUTIONS, LLC            Topic: 100

    Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disordersAnimal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approachesAnimal epilepsy model use typically requires expensive and labor intensive experimentationwith invasive EEG measurements ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. eCPAT: Advancing public park information and technology resources to diverse audiences for healthy communities

    SBC: EnQ LLC            Topic: NCI

    Project Summary Abstract Quality parks provide numerous benefits to individuals and communitiesincluding health cost savings through physical activity and stress reliefincreased tax revenue via augmented property values and attracting businessesand positive social and environmental impacts through outcomes such as civic pride and pollution controlThe Community Park Audit ToolCPATprovides a compreh ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Noninvasive placement and activation of deep-brain stimulating magnetic particles for reduction of drug-seeking behaviors

    SBC: WEINBERG MEDICAL PHYSICS, INC.            Topic: NIDA

    Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe pro ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Rapid Identification of Effects of Defects within Metal Additive Manufacturing (RIED-AM)

    SBC: Intelligent Automation, Inc.            Topic: N18AT013

    Additive manufacturing (AM) systems, especially metal AM, bring revolutionary capabilities, but suffer from a lack of understanding of the defects that exist within the components. In this research, based on selective experimental study and numerical simulations, we will develop an empirical database of defects and their effects on mechanical properties using Laser Powder Bed Fusion (LPBF) technol ...

    STTR Phase I 2018 Department of DefenseNavy
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