Award Data

DESCRIPTION provided by applicant Seasonal influenza flu virus an NIAID category C priority pathogen causes widespread infection resulting in at least million cases of severe illness and deaths worldwide Young children and elderly or immunocompromised individuals are typically at greater risk of severe illness or death from influenza Newly emerging strains can result ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Sanfilippo disease mucopolysaccharidosis type III MPS III is a devastating neurodegenerative lysosomal storage disorder of childhood for which there is no cure or effective treatment available The fundamental cause of MPS III is an inherited mutation in one of the enzymes required to catabolize heparan sulfate HS a glycosaminoglycan which plays importa ...

DESCRIPTION provided by applicant Babesia microti the primary etiologic agent of human babesiosis is a tick borne eukaryotic apicomplexan pathogen that is an increasing threat to the US public health Although B microti is primarily a tick borne pathogen it can be transmitted by transfusion of infected blood Despite the well recognized threat there is no FDA licensed test to screen donor ...

DESCRIPTION provided by applicant The development of vaccine to combat Enterotoxigenic E coli ETEC is vital given the pathogenandapos s global impact on million individuals annually however an entirely new non conventional approach is needed Field studies have suggested that inert antigen based vaccines to combat ETEC have andquot essentially no efficacyandquot Therefore a vaccin ...

This proposal describes a new process to facilitate the shock qualification of submarine components, taking advantage of the similarities between readily observable design features of these components, and correlating them to success or failure in Navy shock qualification tests. To realize this Design Feature Similarity (DFS) approach, we will develop a set of criteria based on this type of readil ...

The US Navy faces daunting energy challenges that will further increase in severity, given the ever-increasing global demand for energy, diminishing energy supplies and demand for enhanced environmental stewardship. Navys environment foot print consists of both emissions and noise generated every day around the world. Additionally, noise is an important issue for the Navy due to the adverse effect ...

Pharad is teaming with the Applied Physics Laboratory of The Johns Hopkins University to propose and investigate the feasibility of wideband (VHF to SHF) RF-to-digital photonic link architectures with real-time digital signal processing (DSP) that can meet the stringent performance metrics of military systems. The key requirements for our wideband DSP linearized RF-to-digital photonic link include ...

This STTR project seeks to overcome the performance limitations of experimental sulfur tolerant SOFC materials by combining two elements of efficient SOFC design: 1) micro-tubular arrays (OD

HYPRES, in collaboration with MIT Lincoln Laboratory and ISQC, proposes to transition superconducting parametric amplifier technology into a robust line of products. In Phase I, we will develop three varieties of superconducting low-noise amplifiers (LNAs) in compact cryogenic microwave packages. These are two types of standing wave devices, lumped-element Josephson parametric amplifier (LJPA) and ...