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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Aminoglycosides with reduced ototoxicity

    SBC: NUBAD, LLC            Topic: NIAID

    PROJECT SUMMARY Aminoglycosides are one of the cheapest and well known antibiotics in clinical use for over years but one of the major limitations in their use is their ototoxicity We are developing fast and low cost methods to develop aminoglycosides with anti ribosomal activities and reduced toxicity In this project we will identify novel aminoglycoside antibacterials that show reduced ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Screening the Ribosome for New Target Sites

    SBC: NUBAD, LLC            Topic: NIAID

    DESCRIPTION provided by applicant Nucleic acids are avenues for drug design both as therapeutics and as targets Here we propose to establish new methods for identifying antibiotic ribosome targets and lead compounds Targeting specific RNA such as rRNA which are involved in proliferation and survival of bacteria is a promising approach We are developing fast and low cost methods to screen s ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Treating collagen induced arthritis CIA with immunoregulatory nanoparticles

    SBC: LeukoSight Inc            Topic: NIAMS

    DESCRIPTION provided by applicant The title of this project is andquot Treating Collagen induced Arthritis with Fc Receptor Activating Nanoparticlesandquot We and others have identified and characterized a population of macrophages with potent immunorergulatory activity The goal of the present proposal is to induce the production of regulatory macrophages R M in mice and determine wheth ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a novel highly effective influenza vaccine

    SBC: Flugen, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Seasonal influenza flu virus an NIAID category C priority pathogen causes widespread infection resulting in at least million cases of severe illness and deaths worldwide Young children and elderly or immunocompromised individuals are typically at greater risk of severe illness or death from influenza Newly emerging strains can result ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Peptide Antibiotic Nucleic Acids

    SBC: NUBAD, LLC            Topic: NIAID

    DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Computational Methods for Dynamic Scene Reconstruction

    SBC: Robotic Research LLC            Topic: N16AT017

    Reconstruction of dynamic scenes is at the limits of the state of the art. It is still challenging to accurately reconstruct models in static scenes. Dynamic scenes add a list of challenges that further complicate the problem:separating the dynamic objects from the motion created by the camera motionMorphological changes to the dynamic object itself. Not only is the system moving, but it is actual ...

    STTR Phase I 2016 Department of DefenseNavy
  7. Subspace Tracking and Manifold Learning Based Heterogeneous Data Fusion for Unexpected Event Discovery

    SBC: INTELLIGENT FUSION TECHNOLOGY, INC.            Topic: AF16AT12

    We aim to develop data-driven heterogeneous data fusion approaches for unanticipated event/target detection, which will be more robust and immune to model mismatch problems encountered by model-based approaches. Considering the low intrinsic dimensionality of the sensor data, we propose several data-level fusion approaches based on some state-of-the-art dimensionality reduction techniques. For lin ...

    STTR Phase I 2016 Department of DefenseAir Force
  8. PTSD SleepAid: A Circadian Rhythm Monitoring and Regulation system for patients with PTSD

    SBC: INTELLIGENT AUTOMATION, INC.            Topic: A16AT014

    The Department of Defense is concerned about adverse effects of circadian rhythm misalignment on sleep hygiene and well-being of service members and veterans who suffer from symptoms of Post-Traumatic Stress Disorder (PTSD). Intelligent Automation, Inc., University of Central Florida RESTORES center and consultants from Lighting Research Center at Rensselaer Polytechnic Institute, propose to devel ...

    STTR Phase I 2016 Department of DefenseArmy
  9. SAM-PDA: A Scalable, Automated and Modular Toolkit for Population Data Analysis

    SBC: INTELLIGENT AUTOMATION, INC.            Topic: A16AT013

    To protect national interests and effectively plan, coordinate and execute military operations, support training and foster partnerships, the U.S. military must better understand populations involved in or impacted by operations. The successful population data analysis is critical in several aspects including but not limited to: assessment of progress towards tactical, operational and strategical ...

    STTR Phase I 2016 Department of DefenseArmy
  10. Novel OSINT Platform for Enhanced OSINT Collection

    SBC: ZUESS, INC.            Topic: A16AT006

    The meteoric rise of personally identifying information (PII) created and shared online is unprecedented. The sheer volume of open source intelligence available on sites such Facebook, Twitter, LinkedIn, message forums, Instagram, etc. makes the task of collecting and organizing OSINT increasingly laborious for analysts. Zeuss has already built and tested an operational product that addresses this ...

    STTR Phase I 2016 Department of DefenseArmy
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