Award Data

PROJECT SUMMARYAminoglycosides are one of the cheapest and well known antibiotics in clinical use for overyearsbut one of the major limitations in their use is their ototoxicityWe are developing fast and low cost methods to develop aminoglycosides with antiribosomal activities and reduced toxicityIn this projectwe will identify novel aminoglycoside antibacterialsthat show reduced ototoxicityComple ...

Autism spectrum disorderASDis a neurodevelopmental disorder characterized by significant deficits in reciprocal social interactionsimpaired communication and restrictedrepetitive behaviorswith a prevalence ofinchildren in the USEarly intervention programs have been shown to be effective for improving IQlanguageand social skills for toddlers as young asmonths of ageDiagnosis of ASD is currently bas ...

Additive manufacturing (AM) systems, especially metal AM, bring revolutionary capabilities, but suffer from a lack of understanding of the defects that exist within the components. In this research, based on selective experimental study and numerical simulations, we will develop an empirical database of defects and their effects on mechanical properties using Laser Powder Bed Fusion (LPBF) technol ...

Materials for thermal protection are required to protect structural components of space vehicles during the re-entry stage, missile launching systems, and solid rocket motors (SRMs). Polymer resins that have high char retention (e.g., phenolic resins) are the most common matrices in the composite materials for rigid thermal protection systems (TPSs) due to their tunable density, lower cost, and hi ...

PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

Target detection and recognition is a challenging problem because of changes in appearance, viewing direction, occlusion and other covariates. Systems that can accurately and efficiently detect and track objects can provide several benefits in surveillance, monitoring and other applications. As part of this effort, we propose to develop a robust learning-based approach to detect, track and recogni ...

This is a prototype system that will take raw observation data, detect and characterize maneuvers, and use reinforcement learning to understand and react to evasive RSO behaviors in near real time. This will provide a framework to evaluate autonomous behavior strategies, such a safety, effectiveness, and robustness to manipulation. This work will enable surveillance operators to distinguish betwee ...

Space superiority requires space protection and space situational awareness (SSA), which rely on rapid and accurate space object behavioral and operational intent discovery. The focus of this project is to develop a stochastic approach for rapid discovery of evasive satellite behaviors. Designing the innovative decision support tool has numerous challenges: (i) partial observable actions; (ii) eva ...

Additive Manufacturing (AM) is a modern and increasingly popular manufacturing process for metallic components, but suffers from well known problems of inconsistent quality of the finished product. Process monitoring and feedback control are therefore crucial research areas with a goal of solving this problem. To address this concern, X-wave Innovations, Inc. (XII) and the University of Dayton Res ...

In response to the challenges described in AF173-CT05, Applied Defense Solutions (ADS) and the University of New Mexico (UNM) (equivalently, the ADS Team) propose to research and develop innovative validation and verification (V&V) algorithms for spacecraft GN&C. The ADS Team is unique in that it brings operational flight GN&C software experience (ADS) with cutting edge research on algorithm V&V ( ...