Award Data

DESCRIPTION provided by applicant Seasonal influenza flu virus an NIAID category C priority pathogen causes widespread infection resulting in at least million cases of severe illness and deaths worldwide Young children and elderly or immunocompromised individuals are typically at greater risk of severe illness or death from influenza Newly emerging strains can result ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

The role of UASs in the DoD has been continuously growing and is expected to show much higher growth rates in operations in the near future. A pressing need for such platforms is the need to be able to satisfy multiple mission objectives, without "compromising" on efficiency. This need is further exacerbated by increasing fuel prices, that dictates higher aerodynamic efficiencies across the comple ...

The prevalence of off earth landing missions both proposed and undertaken has been steadily increasing. With the proposal of missions, not only to Mars, but also to comets, asteroids and outer planet moons, the ruggedness and robustness of equipment must meet the challenges of ever harsher environments. As a part of these missions, researchers wish to analyze the materials which make up the surfac ...

Despite the rapid commercialization of additive manufacturing technology such as selective laser melting, SLM, there are gaps in process modeling and material property prediction that contribute to slow and costly process qualification and product certification. To address these gaps, CFDRC and our partner Dr. Kevin Chou, University of Alabama, will develop multiple computationally efficient, high ...

The proposed Low Cost Nanolauncher (LCN) is an upper stage using a new, inexpensive propulsion system. The Phase I program will combine several technologies with a simple design strategy to produce a flight-weight propulsion system that is easy to fabricate and operate. Self pressurizing propellants will minimize complexity of the propulsion system and vortex cold-wall technology will be used to ...

Project Summary Human respiratory syncytial virus (RSV) is recognized as the single most important viral cause of acute respiratory disease in infants and young children worldwide. Elderly populations and immunocompromised individuals are also at significant risk for serious RSV disease. Despite this very substantial disease burden imposed by RSV worldwide, there are no vaccines available. Severa ...

DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

DESCRIPTION (provided by applicant): Scleroderma is a devastating autoimmune disease with a chronic course, involving the overproduction of collagen leading to fibrosis of the skin and connective tissues. The disease has a range of symptoms including pain,stiffness and swelling of the joints, shortness of breath and gastrointestinal complications. More than 50% of patients with the aggressive form ...

DESCRIPTION (provided by applicant): The overall objective of the proposed research is to fully develop and conduct clinical translation of a novel technology that provides minimally invasive surgeons an ability to visualize exposed organ surfaces as wellas structures hidden by them, together with a true appreciation of depth. A long-standing need in minimally invasive laparoscopic surgery has bee ...