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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Emodin as a complementary dietary therapy to reduce toxicity of 5 fluorouracil

    SBC: AcePre, LLC            Topic: NCCIH

    PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Mitigating Injurious Falls in Older Adults Through Non-Injurious Fall and Gait Analysis From Floor Vibrations

    SBC: ADVANCED SMART SYSTEMS AND EVALUATION TECHNOLOGIES, LLC            Topic: NIA

    Project Summary and Abstract Falls are the leading cause of death due to injuryThis simple motion is so common thatof community dwelling older adultsandof long term care facilities will experience a fall in the coming yearThe risk of falling substantially increases for those having Alzheimer s disease and related dementiasand those with Parkinson s diseaseThe financial burden is significant with f ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Gene Therapy for Type 1 Diabetes

    SBC: Endsulin LLC            Topic: NIDDK

    TypeDiabetes MellitusT DMis an increasingly prevalent form of diabetes in which the insulin producingcells of the pancreas are destroyed by an autoimmune attackand as a resultno endogenous insulin is producedMost often diagnosed in childrenmillion Americans suffer from T DMandnew cases are diagnosed annually worldwideT DM profoundly impacts patientshealth and quality of life due to the constant ne ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. CCN3-derrived peptides to treat liver injury

    SBC: BLR Bio            Topic: 200

    Project Summary Chronic liver disease is becoming a major public health issue with estimates of up to 40% prevalence of non- alcoholic fatty liver disease (NAFLD) and 12% with non-alcoholic steatohepatitis (NASH) in the U.S. Liver disease and cirrhosis was the 12th leading cause of mortality in the U.S. in 2014. Obesity and metabolic syndrome are important causes of fatty liver disease or steatosi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Targeted Nanotherapy to Donor Organ Endothelia Modulates Early Immune Responses and Protects Against Late Graft Failure

    SBC: ToleRaM NanoTech LLC            Topic: NIBIB

    ABSTRACT Transplantation is an accepted and highly successful therapy for end stage organ diseaseWhile success rates and survival have risen steadilydue largely to improved immunosuppression regimesthere is a growing appreciation that damage and inflammation that occur early in the life of the graftsignificantly impact chronic rejection and thus long term survivalCentral to these early event injur ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. TAPS-ESP: Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform: Technologies to Increase Screening in Primary Care to Reduce Behavioral Health Disparities

    SBC: COG ANALYTICS, LLC            Topic: 102

    ABSTRACTTAPS ESP Language accessibility and cultural awareness are essential elements of quality healthcareLimited English ProficiencyLEPindividuals are less likely to self identify a need for behavioral health serviceswhich results in longer duration of untreated disordersAccurate identificationdiagnosisand treatment are entirely dependent on a linguistically accurate screening and assessmentespe ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Wearable Shear Wave Tensiometry for Tracking Tendon Load during Dynamic Movement

    SBC: Design Concepts, Incorporated            Topic: NIAMS

    Project Summary The long term goal of this project is to develop a wirelesswearable system to estimate the tension in tendons of the legs during dynamic movementsTendon tension provides an estimate of muscle forcewhich is important information for understanding biomechanical behavior in all types of movementthough it has previously been difficult to measureRecent advances have shown that skin moun ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Preclinical Development of 2nd Generation HIV Maturation Inhibitors

    SBC: DFH Pharma, Inc            Topic: 400

    Project SummaryDespite advances in the development of HIV drugs there remains a need for new therapiesToxicities associated with long term use of many of the approved HIV drugs coupled with the development of resistance drives the need for new and novel antiviralsMaturation inhibitorsMIsrepresent one such class of HIV therapiesHIV maturation inhibitors block virus replication by disrupting the con ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Catheter Development for Epicardial Atrial Gene Painting

    SBC: RITHIM BIOLOGICS INC            Topic: NCATS

    ABSTRACT Atrial fibrillationAFis the most common rhythm disturbance in the US and other developed countriesAF significantly affects the lives of the afflictedcausing symptoms that range from palpitations to fatigueweakness and activity intoleranceand substantially increasing the risks of strokecongestive heart failure and deathThe impact on public health is substantialwith more thanhospital admiss ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Building an evidentiary case for circulating GHBP as a biomarker for drug-associated stunting of growth

    SBC: REVERAGEN BIOPHARMA, INC.            Topic: NICHD

    There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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