Award Data

DESCRIPTION provided by applicant Seasonal influenza flu virus an NIAID category C priority pathogen causes widespread infection resulting in at least million cases of severe illness and deaths worldwide Young children and elderly or immunocompromised individuals are typically at greater risk of severe illness or death from influenza Newly emerging strains can result ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Sanfilippo disease mucopolysaccharidosis type III MPS III is a devastating neurodegenerative lysosomal storage disorder of childhood for which there is no cure or effective treatment available The fundamental cause of MPS III is an inherited mutation in one of the enzymes required to catabolize heparan sulfate HS a glycosaminoglycan which plays importa ...

DESCRIPTION provided by applicant Babesia microti the primary etiologic agent of human babesiosis is a tick borne eukaryotic apicomplexan pathogen that is an increasing threat to the US public health Although B microti is primarily a tick borne pathogen it can be transmitted by transfusion of infected blood Despite the well recognized threat there is no FDA licensed test to screen donor ...

DESCRIPTION provided by applicant The development of vaccine to combat Enterotoxigenic E coli ETEC is vital given the pathogenandapos s global impact on million individuals annually however an entirely new non conventional approach is needed Field studies have suggested that inert antigen based vaccines to combat ETEC have andquot essentially no efficacyandquot Therefore a vaccin ...

This SBIR Phase I project proposes to create an innovative educational game that engages secondary school students in learning about the science of anaerobic digestion and the business of biogas production. The Simulated Anaerobic Digester Learning Tool is a casual, simulation-based game that teaches students about the physicochemical operation of an anaerobic digester, as well as an entrepreneuri ...

The broader impacts/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is in the development of energy-saving window products that are aesthetically pleasing. Aerogel window products have the potential to be transformative to the fenestration industry, due both to the high translucency and low thermal conductivity of the aerogel materials and the particular adva ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is found in the proposed technology development that facilitates direct, ubiquitous acquisition of key biomedical data, with little or no human intervention or introduction of errors, has the potential to reduce the costs of healthcare and to revolutionize healthcare delivery throughout our so ...

The broader impact/commercial potential of this project is the development of a continuous and low-cost spray-pyrolysis process for making mixed metal oxide (MMO) materials that can be used in the petroleum and chemicals synthesis, precursors for solar panels, electrode materials, fuel cells, oxygen selective membranes, and chemical sensors. Of particular interest are crystalline pyrochlore mixed ...

The broader impact/commercial potential of this project is determined by new consumer products and new industries which would flourish on portable and reliable atomic clocks, gyroscopes, and magnetometers when they become available. Proposed compact thermal and magnetic enclosure reduces the most bulky part of such devices and provides an avenue for further miniaturization. A chip-scale atomic clo ...