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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. An HIV Vaccine Strategy Based on Priming with rVSV Expressing FLSC

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: R

    DESCRIPTION Based on the prevailing evidence we believe that a highly effective vaccine for HIV prophylaxis must induce long lasting broadly cross reactive antibody responses to envelope that exhibit antiviral activity as well as multi antigen polyfunctional CD and CD T cell responses that produce antiviral chemokines and cytokines and are possibly biased towards an effector memory phenot ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Enzyme Switch: many reporter molecules from a single-molecule-sequencing product

    SBC: CAERUS MOLECULAR DIAGNOSTICS INCORPORATED            Topic: NHGRI

    DESCRIPTION provided by applicant Even as the cost and throughput of commercial sequencers has continued to improve over the last years there is still a need to further reduce sequencing costs to increase throughput and sequencing accuracy and to reduce the costs associated with sample preparation Single molecule methods such as the Pacific Biosciences or nanopore technologies have the pot ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Aptamer-Based Detection of Cardiac Biomarker Glycosylation States Using APT-SNAP

    SBC: Proteovista LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Aptamer Based Detection of Cardiac Biomarker Glycosylation States Using APT SNAP Arrays PIs Christopher L Warren and Mary S Ozers The presence of cardiac related biomarkers in patient biospecimens can provide important insight into diagnosis of cardiovascular disease its progression and optimal therapies for treatment Most of the cardiac biomarkers in cli ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Novel caveolin modulators as therapeutics for uveitis

    SBC: E AND B TECHNOLOGIES, LLC            Topic: N

    DESCRIPTION provided by applicant Novel caveolin modulators as therapeutics for uveitis Project Summary This research proposal seeks to develop a novel therapy for uveitis based upon modulation of inflammatory signaling via caveolae Uveitis drives of blindness affecting people of working age and producing significant disability in patients with chronic disease Caveolin modulators such ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. I-Corp Customer Discovery of Automated Wireless Microinfusion Systems

    SBC: FLUID SYNCHRONY, LLC            Topic: 300

    DESCRIPTION provided by applicant Our vision is to realize a smart vivarium whereby a network of implanted microinfusion pumps may be remotely controlled from a single computing station Automation of drug administration and on demand dose adjustment in freely moving animals offers greater throughput and improved outcomes compared to existing technologies Towards this end this proposal focus ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Sample Pretreatment for Human Fluids

    SBC: Sonata Biosciences Inc            Topic: 400

    DESCRIPTION provided by applicant In this proposal we seek to develop a new method and instrument to reduce the complexity of protein mixtures derived from human fluids with an eye to discovery of very low abundance protein biomarkers The proposed method accomplishes two tasks it reduces the dynamic range of the protein mixture by three or more orders of magnitude and it concentrates proteins ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Recombinant Protein for Mitigating Total Body Radiation Injury

    SBC: THERASOURCE, LLC            Topic: NIAID

    DESCRIPTION provided by applicant This SBIR Phase I proposal is intended to demonstrate the feasibility of developing a novel and effective therapeutic agent for acute radiation injury The threat of nuclear terrorism remains high and there is a possibility of a nuclear power plant leak both of which can cause acute radiation injury at a large scale Currently there are no therapeutic agents ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a novel highly effective influenza vaccine

    SBC: FLUGEN INC            Topic: NIAID

    DESCRIPTION provided by applicant Seasonal influenza flu virus an NIAID category C priority pathogen causes widespread infection resulting in at least million cases of severe illness and deaths worldwide Young children and elderly or immunocompromised individuals are typically at greater risk of severe illness or death from influenza Newly emerging strains can result ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Peptide Antibiotic Nucleic Acids

    SBC: NUBAD LLC            Topic: NIAID

    DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

    SBC: POSIT SCIENCE CORP            Topic: NIA

    DESCRIPTION provided by applicant The primary objective of the current project is to develop and evaluate the efficacy of on line brain plasticity based computerized assessment tool and training program for the prevention and delay of the onset of Alzheimerandapos s disease AD This novel therapeutic strategy is designed to re connect and reinvigorate Default Network DN brain areas by in ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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