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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Proteolytic Imaging of Remodeling Myocardium

    SBC: Micro Vide, LLC            Topic: NHLBI

    DESCRIPTIONprovided by applicantProteolytic Imaging of Remodeling Myocardium Abstract Heart attacksi emyocardial infarction or MIoccur in more thanmillion patients annuallyAdvances in interventional and pharmacological therapies have dramatically improved survival following the initial MIand patients are often surviving acute MI with more extensive myocardial injuryConsequentlythe number of patien ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. A NEW HOLOGRAPHIC 3D CAMERA FOR FUNDUS IMAGING

    SBC: CELLOPTIC            Topic: N

    A NEW HOLOGRAPHIC D CAMERA FOR FUNDUS IMAGING Abstract In the United States retinal disease is the most common cause of visual impairment with age related macular degeneration AMD and diabetic retinopathy DR being the most common retinal diseases For each of the above conditions high resolution and three dimensional D imaging of the retina retinal vasculature choroid and or retinal ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Novel noninvasive diagnostic technology for dynamic imaging of mitochondrial bioenergetics in breast cancer patients

    SBC: Robin Medical, Inc.            Topic: 102

    Summary Breast cancer is the second most common and the major cause of cancer related death of women in the USA The last decade has witnessed major advancement of therapeutic drugs and tools while noninvasive diagnostic imaging tools to measure interventions received much less attention Currently the mainstay of noninvasive imaging in breast cancer relies primarily on anatomic imaging Metabol ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Aminoglycosides with reduced ototoxicity

    SBC: NUBAD, LLC            Topic: NIAID

    PROJECT SUMMARY Aminoglycosides are one of the cheapest and well known antibiotics in clinical use for over years but one of the major limitations in their use is their ototoxicity We are developing fast and low cost methods to develop aminoglycosides with anti ribosomal activities and reduced toxicity In this project we will identify novel aminoglycoside antibacterials that show reduced ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Multivalent Oral Vaccine against Enterotoxigenic Escherichia coli and Enteric Fevers

    SBC: PROTEIN POTENTIAL LLC            Topic: NIAID

    Enteric diseases caused by enterotoxigenic E coli ETEC strains Shigella spp and Salmonella Typhi all of which are NIAID Category B priority agents collectively affect andgt million people annually worldwide Currently there is no vaccine against ETEC or shigellosis A typhoid vaccine exists An affordable effective oral multivalent vaccine against all organisms would have enormous ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. High quality compact portable low field head MRI with ultra fast gradients

    SBC: Weinberg Medical Physics, Inc.            Topic: 108

    The company has shown that with by using ultra fast strong gradients inexpensive low field MRI systems can collect images that are comparable in quality signal to noise ratio resolution to conventional e g T MRI The company already has made large strides in commercializing this advantage by conducting human studies with a prototype and by attracting investors The prototype was built ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. PfSPZ Vaccines Quality Systems Manufacturing Regulatory and Clinical Quality and Data Management Support for Product Commercialization

    SBC: SANARIA INC.            Topic: NIAID

    ABSTRACT Sanaria s Plasmodium falciparum Pf sporozoite SPZ vaccines development program is receiving overwhelming global support Eleven trials of Sanaria s two primary PfSPZ vaccines which include subjects were initiated in late Tanzania U S or will start in early Kenya Ghana Equatorial Guinea EG Burkina Faso Germany and the U S These trials will assess to ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Targeted Epigenetic Therapy for Triple-Negative Breast Cancer

    SBC: PARKSIDE SCIENTIFIC INC.            Topic: 102

    DESCRIPTIONprovided by applicantTriple negative breast cancerTNBCis one of the most aggressive forms of human cancerand currently has no targeted therapyChemotherapy is the only available treatment for TNBC patientsbut is deleterious and not effective once tumor spreadsTNBC represents a major unmet medical needaboutof breast cancer incidenceswomen worldwide inare TNBCTNBC disproportionally affects ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Screening the Ribosome for New Target Sites

    SBC: NUBAD, LLC            Topic: NIAID

    DESCRIPTION provided by applicant Nucleic acids are avenues for drug design both as therapeutics and as targets Here we propose to establish new methods for identifying antibiotic ribosome targets and lead compounds Targeting specific RNA such as rRNA which are involved in proliferation and survival of bacteria is a promising approach We are developing fast and low cost methods to screen s ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. An Aging Heart Model for Drug Discovery

    SBC: Invivosciences, Inc.            Topic: NIA

    Project Summary Abstract Cardiovascular drugs are primarily prescribed to older peoplertyears of agesince the prevalence of chronic heart failure and fibrillation increases with ageThe incidence of other diseasesincluding cancer and neurological disordersincreases with agetooAny medications hold potential risks to cause adverse eventsThereforethe risks of medications in older people also increase ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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