Award Data

DESCRIPTION (Scanned from the applicant's description): The proposed study involves an evaluation of the dose response to recombinant human CC10 in the preterm lamb, a surfactant-dependent model of neonatal/infant respiratory distress syndrome (IRDS). The preterm lamb model was used in the clinical development of artificial surfactants for the treatment of I ...

DESCRIPTION (Applicant's abstract): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (AEGIS), a new, "rule based" molecular re ...

DESCRIPTION (Applicant's abstract): A substantial commercial potential exists for software tools that allow a biomedical research scientist to use genomic data to form experimentally testable hypotheses. These will be used to exploit genomic sequence data to understand the aetiology of disease, to improve diagnostic tools, and to develop more effective therapies. T ...

This proposal's long-term goal is to develop radiographic phantoms to address the following critical needs in the emerging field of digital x- ray imaging: quality control procedures for daily operations; quality assurance methods for users to evaluate products, perform acceptance testing and determine optimum system operating parameters; development tools for manufacturers to test new hardware an ...

This proposal addresses development of new imaging technology for noninvasive quantitative measurement of apoptosis in vivo. Apoptosis is genetically defined cell death. Understanding the role of apoptosis is critical to the development of new molecular-based therapeutic modalities. An apoptosis-imaging agent could be used to modify therapy for cancer patients, and to monitor cardiac transplant pa ...

DESCRIPTION (provided by applicant): Our goal is to produce active recombinant proteins involved in cancer progression and other important cellular processes. Recombinant proteins in biomedical research have now become an essential tool to study many aspects of cellular biology. Genes coding for several important cellular function such as tumor suppres ...

Project Summary Human respiratory syncytial virus (RSV) is recognized as the single most important viral cause of acute respiratory disease in infants and young children worldwide. Elderly populations and immunocompromised individuals are also at significant risk for serious RSV disease. Despite this very substantial disease burden imposed by RSV worldwide, there are no vaccines available. Severa ...

DESCRIPTION (provided by applicant): Polychromatic flow cytometry [FC] is one of the most powerful analytical techniques routinely used in immunology. Flow cytometry plays a critical role in several growing clinical applications: leukemia and lymphoma immunophenotyping for diagnosis and sub-categorization (now using 8-10 colors); in CD4/CD8 measurement in HIV-positive patients; and in HLA typing f ...

DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...