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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Feasibility of mHealth technology-enabled service for remote observed therapy of methadone and COVID-19 screening for patients in an opioid treatment program

    SBC: EMOCHA MOBILE HEALTH INC.            Topic: NIDA

    PROJECT SUMMARY Methadone remains a cornerstone of treatment for opioid use disorders (OUD). Daily or frequent supervised treatment with visual confirmation of ingestion (directly-observed therapy or “DOT”), is the standard of care for methadone treatment in federally licensed opioid treatment programs (OTPs) in the United States. DOT ensures adherence and mitigates the risk of medication pois ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Nucleotide inhibitors as precision medicine in breast cancer

    SBC: RECOMBINATION THERAPEUTICS LLC            Topic: 102

    Breast cancer is the most frequently diagnosed cancer in women, and 15-20% of patients have triple negative breast cancer (TNBC) which results in a 70% mortality rate within 5 years of diagnosis. 10-15% of TNBC patients possess heritable mutations in the BRCA1/BRCA2 tumor suppressor genes which promote homologous recombination (HR) of DNA double-strand breaks (DSBs). BRCA-mutated cells are highly ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Determination of circulation factors that mediate the health benefits of exercise in mitochondrial aging

    SBC: CYTEGEN CORP            Topic: NIA

    Project Summary/Abstract: This proposal seeks to test the hypothesis that endurance exercise stimulates the release of circulating factors that improve mitochondrial fitness. CyteGen’s goal is to identify these endogenous factors and engineer them to treat diseases in which mitochondrial dysfunction is central. These diseases include neurodegenerative and other diseases associated with aging, as ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Preclinical proof of concept validation of a novel endoscopic treatment for urethral stricture disease

    SBC: CELEFLUX LLC            Topic: 400

    PROJECT SUMMARY/ABSTRACT CeleFlux is developing a medical device which enables urologists to provide long-lasting, minimally invasive urethral reconstruction to treat male urethral stricture - via endoscopic delivery of a temporary tissue graft implant. Urethral stricture disease progressively narrows the urethral lumen, similar to a band of scar tissue. This results in painful and frequent urinat ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Novel AMPK Activators for the Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus

    SBC: NephroDI Therapeutics, Inc.            Topic: 400

    PROJECT SUMMARYNephrogenic diabetes insipidus (NDI) is a disease characterized by the production of very large quantities of dilute urine from an inability of the kidney to respond to vasopressin. NDI can be either congenital or acquired. Acquired NDI is a common side effect of lithium therapy. Lithium-induced NDI patients produce over 3 L/d of dilute urine. Lithium is the first-line treatment for ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Functionalized perfluorocarbon nanoemulsions for enhanced cell labeling for fluorine-19 MRI detection

    SBC: CELSENSE, INC.            Topic: NIBIB

    This project aims to develop and commercialize a novel MRI probe technology for the cell therapy tools market. This project will transfer technology invented in the academic lab of Dr. Ahrens at UCSD, to Celsense, Inc., an established company that offers imaging agents for visualizing and quantifying the trafficking of cell therapies and inflammation in the body using magnetic resonance imaging (M ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Improving data capture in clinical research using a chatbot

    SBC: Dokbot, LLC            Topic: NLM

    PROJECT SUMMARY . Collecting complete and accurate outcome data directly from research participants is becoming increasingly important. Clinical researchers needs a cost-effective approach to capture high-quality patient-reported outcomes. Typically, data captured directly from participants is through self-administered questionnaires or through a human interviewer, each with their own advantages ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Enabling membrane protein structural analysis: Tools for capillary diffusion crystallization and remote in situ diffraction experiments

    SBC: Elk Valley Enterprises, Inc.            Topic: 400

    Project SummaryThis proposal is to develop an integrated capillary counter diffusion-based approach to in situ collection of macromolecule diffraction data. The method to be developed will enable both cryogenic and ambient temperature data collection, with the latter being critical to structure-based drug design. The approach is based on a capillary that is pre-mounted in a holder that facilitates ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Nature-inspired Aqueous Biodegradable Adhesives for Abdominoplasty

    SBC: ALEO BME INC            Topic: NIBIB

    Project Summary Seroma is the most common adverse effect of many surgical procedures and is estimated to occur in up to half of all abdominoplasties. Because abdominoplasty is one of the most commonly performed aesthetic procedures in the United States (150,000/year) seroma formation is a major concern. Problems related to seroma accumulation include patient discomfort, incisional disruption and s ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Dianomi Therapeutics- Using Mineral Coated Microparticles as an Improved Sustained Delivery Method of Anakinra for Treatment and Prevention of Gout with a Single Injection

    SBC: Dianomi Therapeutics, Inc.            Topic: NIAMS

    Project SummaryGout is a prevalent inflammatory arthritic disease that affects 8.3 million people in the US. As current treat- ments are often inadequate, the impact of gout on the economy is a substantial burden. Gout develops when excessive levels of uric acid accumulate in tissue and form crystalline deposits in various joints, causing excru- ciating pain and inflammation. Without treatment, th ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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