Award Data

DESCRIPTION provided by applicant Nearly percent of death and disease worldwide is linked to environmental factors WHO therefore it is critical that the general public has basic understanding of how the environment affects their health and how they might protect themselves against environmental exposures Unfortunately environmental health content is typically covered on a very ...

DESCRIPTION provided by applicant Babesia microti the primary etiologic agent of human babesiosis is a tick borne eukaryotic apicomplexan pathogen that is an increasing threat to the US public health Although B microti is primarily a tick borne pathogen it can be transmitted by transfusion of infected blood Despite the well recognized threat there is no FDA licensed test to screen donor ...

DESCRIPTION provided by applicant The development of vaccine to combat Enterotoxigenic E coli ETEC is vital given the pathogenandapos s global impact on million individuals annually however an entirely new non conventional approach is needed Field studies have suggested that inert antigen based vaccines to combat ETEC have andquot essentially no efficacyandquot Therefore a vaccin ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Sanfilippo disease mucopolysaccharidosis type III MPS III is a devastating neurodegenerative lysosomal storage disorder of childhood for which there is no cure or effective treatment available The fundamental cause of MPS III is an inherited mutation in one of the enzymes required to catabolize heparan sulfate HS a glycosaminoglycan which plays importa ...

DESCRIPTION provided by applicant Lassa fever virus LASV and Machupo virus MACV are hemorrhagic fever arenaviruses which are classified as Category A Agents Currently there are no licensed LASV or MACV vaccines and LASV MACV therapy is limited to use of the nucleoside analog ribavirin which is only partially effective and associated with significant side effects The impact of arenavirus ...

DESCRIPTION provided by applicant Ebola and Marburg viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as the biosafety level agents Currently there is no effective vaccine or therapeutic treatment against filoviral i ...

Q-Peak, Inc. in collaboration with CREOL proposes to develop a novel concept of long-wave IR (LWIR) femtosecond laser system. Current laser systems suffer from complexity due to the use of multiple nonlinear stages to achieve the desired wavelength and have issues with power scaling. The proposed system will consist of 2.5 um femtosecond regenerative amplifier system pumping a single OPA stage bas ...

Antimicrobial treatment of military textile systems is intended to provide enhanced protection to the Warfighter in the field by preventing colonization of harmful bacteria that cause problems such as odor, dermatitis, and skin irritation. Current treatments can impart antimicrobial functionality to textiles; however, they all possess broad-spectrum antimicrobial activity, affecting all skin bacte ...

To achieve the goals of this program improving spectral coverage and output power of monolithic QCL sources as well as the development of a production and manufacturing plan - we propose to develop in collaboration with MIT Lincoln Laboratory a broadly tunable high power source that is based on Eos"proprietary QCL array technology. The current generation of Eos"commercially available fully packag ...