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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Hydronic, High-Speed, Focal Thermal Stimulator

    SBC: ALA SCIENTIFIC INSTRUMENTS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Cloning of the hot and cold thermal receptors has advanced the understanding of the molecular basis of thermal sensation. Two important remaining questions to be addressed are the identification of additional thermal receptor genes and the elucidation of the mechanism(s) that enable the receptor proteins to alter gating properties in response to changes in temp ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  2. Ultra-micro oxygen sensor development

    SBC: Biocurrents Research, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall aim of this STTR proposal is to take an innovative, successful; laboratory based technology and transfer it to the commercial sector. Specifically, we wish to establish the capabilities within the Company to manufacture reliable, robust and inexpensive ultra-micro oxygen sensors suitable for electrochemical applications related to cellular metabolis ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. Novel pharmacotherapies for treatment of ADHD

    SBC: Biostream Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Attention-deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition characterized by hyperactivity, inattention and impulsivity, typically in school-aged boys. Psychostimulants, including methylphenidate and amphetamines, are commonly used to alleviate symptoms of ADHD. However, these medications are typically associated with undesirable sid ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a peptide array synthesis system

    SBC: Boston Array Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of phase I and II of this proposal is to develop microarray-based methods for high throughput profiling of proteins. This will be done in two different ways, one based on arrays of 100s of thousands of distinct peptides on 1 cm2 chips that can be used to fingerprint proteins, the other based on thousands or tens of thousands of antibodies again ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  5. Atiprimod to Treat Multiple Myeloma and Bone Resorption

    SBC: Callisto Pharmaceuticals, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this proposal is to evaluate the potential of atiprimod, a drug previously explored for treating rheumatoid arthritis, to treat human multiple myeloma (MM) and other metastatic osteolytic bone diseases. Atiprimod is an orally bioavailable drug that originally completed phase I/lla clinical trials in rheumatoid arthritis patients, with patient exposu ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  6. Video Analysis for Nighttime Surveillance and Situational Awareness

    SBC: Charles River Analytics, Inc.            Topic: N/A

    Interpretation of video imagery is the quintessential goal of computer vision. The ability to group moving pixels into regions and then associate semantic labels with those regions has long been studied by the vision community. Only recently have thecomponent technologies matured sufficiently to make this goal attainable for well-defined scenarios. We propose a system for semantic interpretation o ...

    STTR Phase I 2003 Department of DefenseDefense Advanced Research Projects Agency
  7. Method for Discovering Novel Transcriptional Regulators

    SBC: CROSSLINK GENETICS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Regulation of gene expression by transcription factors is one of the most fundamental biological processes. The pharmaceutical manipulation of this process would open doors toward new approaches to treatment of cancer and other major diseases. We aim to develop a novel, comprehensive technology for manipulation of gene expression based on synthetic analogu ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  8. Gene Expression of Viable Ovarian Cancer Cells

    SBC: Endomedix, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Molecular profiling of gene expression is a powerful tool that can be used to stage human tumors and categorize them with respect to projected prognosis and therapeutic responsiveness. This technology has been applied most effectively to leukemias and lymphomas for which it is relatively easy to obtain highly enriched pools of tumor cells. Similar approaches ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  9. Prevention of graft rejection by catalytic antioxidants

    SBC: Eukarion, Inc.            Topic: N/A

    DESCRIPTION (provided by the applicant): Transplantation represents the only therapy for end-stage organ failure caused by a variety of incurable diseases. However, rejection by the host represents a major obstacle to long-term survival of transplants. While acute rejection is currently controlled by immunosuppressive drugs, continuous treatment with these non-selective agents impairs the entire ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  10. Inhibition of corneal graft rejection by antioxidants

    SBC: Eukarion, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Corneal transplantation is the most common form of tissue allotransplantation (47,000 cases per year). However, 15% of the grafts are rejected within a year in "high risk" patients. In "low risk" patients, immunosuppressive drug treatment is associated with induction of cataracts, glaucoma and infections. In fact, despite the high rate of success, more corneal ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
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