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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Therapeutic Intermittent Compression Socket

    SBC: Liberating Technologies, Inc.            Topic: N/A

    The purpose of this project is to develop a device that provides rapid intermittent compression to the residual limb of amputees that do not have good blood flow in their limbs. The device will be built into the prosthetic socket to provide the user with portable therapy throughout the day, which will free the user from being confined to a chair for up to six hours each day to receive the prescrib ...

    SBIR Phase I 2014 Department of Education
  2. Development of Gap Junction Inhibition Therapy for Alcoholic Liver Disease

    SBC: HEPROTECH, INC.            Topic: NIAAA

    ? DESCRIPTION (provided by applicant): Alcoholic liver disease is a highly prevalent and costly condition affecting millions of people globally. Alcohol results in high morbidity and mortality an is responsible for nearly 4% of all deaths worldwide. Despite the tremendous societal and economic burden, there is no approved therapeutics for alcoholic liver disease. Instead, the standard of care ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Clinically suitable approach for gene-mediated therapy of cirrhosis.

    SBC: ADVANTAGENE, INC            Topic: NIAAA

    Abstract Persistent injury to the liver can cause chronic inflammation and dysregulated deposition of extracellular matrix (ECM), leading to accumulation of fibrotic scar tissue and eventually cirrhosis. While fibrosis is a normal wound healing response, in excess, it can further injure tissue and activate pro-fibrotic cells, resulting in a positive feedback loop. Scar tissue is not static, ECM re ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Novel Algorithm for Free Testosterone Determination

    SBC: Function Promoting Therapies, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): The measurement of testosterone levels is central to the diagnosis of androgen disorders in men and women. Circulating testosterone is bound largely to sex hormone binding globulin (SHBG) and albumin; only the unbound or free fraction is biologically active. Therefore, in conditions that affect SHBG concentrations, such as aging, obesity, and diabetes, the dete ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. A synthetic biology platform to identify novel anti-aging natural products

    SBC: Radiant Genomics, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): The ultimate goal of research into the biology of aging is to identify pharmaceutical interventions to increase both lifespan and healthspan of humans. The natural product rapamycin has been shown to significantly extend the lifespans of all model organisms tested including fungi, flies, worms, and mice. However, chronic treatment with rapamycin also causes unw ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Wearable Vibration Device to Prevent Bone Loss in Postmenopausal Women

    SBC: Theranova LLC            Topic: NIA

    DESCRIPTION (provided by applicant): Osteoporosis affects 10 million Americans over the age of 50 and leads to 1.5 million bone fractures per year, primarily in women. For senior citizens who suffer fractures of the hip, 20% will die within one year. Unfortunately, pharmacological treatments for osteoporosis have been met with resistance due to significant adverse side effects. This project aims ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Nanowire Sensor Array-based Assay for Early Diagnosis of Alzheimer's Disease

    SBC: Innosense Llc            Topic: NIA

    DESCRIPTION (provided by applicant): Over 5 million Americans are currently believed to have Alzheimer's disease (AD), the most common form of dementia. This number could reach 16 million by 2050. AD is a terminal, progressive brain disorder with no knowncause or cure. AD leads to memory loss, confusion, impaired judgment, personality changes, disorientation, and the inability to communicate. ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Mobile Older Driver Assessment and Training Simulator (MODATS)

    SBC: Systems Technology, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): This project is collaboration between Systems Technology, Inc. (STI) and the University of Massachusetts, Amherst (UMass) both with extensive driving simulator experience and research with older drivers. It is proposedto develop an assessment and training system with a simulator to mediate the traffic safety problems of older drivers. The simulation software is ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Development and validation of a sensitive and selective assay for quantitating so

    SBC: Acumen Pharmaceuticals, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): In the United States in 2013, 5.2 million people are estimated to suffer from Alzheimer's disease, with as many as 50% being undiagnosed [Alzheimer's Association 2013]. Current diagnostic technologies for Alzheimer's disease are based on the levels of total soluble amyloid beta (Abeta) peptide in plasma and/or cerebrospinal fluid (CSF), levels of ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Discovery of novel Alzheimer's Disease-specific antigens/epitopes and their captu

    SBC: AVANTGEN INC            Topic: NIA

    DESCRIPTION (provided by applicant): Since substantial neuronal loss has already occurred by the time Alzheimer's Disease (AD) manifests clinically, considerable research has been directed towards developing biomarkers for the reliable diagnosis of mild ADand the prodromal stage of mild cognitive impairment. The best studied biomarkers, A1-42 peptide and tau/P-tau, can distinguish cohorts of ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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