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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Automated Electrophysiology Assessment of Drug induced Cardiotoxicity Based on Parallel Noninvasive Nanoelectrode Array

    SBC: CYION TECHNOLOGIES LLC            Topic: NIBIB

    Summary Drug safety issues pose a serious challenge to the health and well being of patients The development of our innovative technology aims to address a significant gap in the in vitro assessment of drug induced cardiotoxicity which is the number one reason for withdrawals of all marketed drugs as well as the premature termination of promising drug development candidates Pressured by the eno ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Drug eluting Brachytherapy Implants for Chemo radiation Therapy

    SBC: TheraNano LLC            Topic: 102

    Prostate cancer PCa is the second leading cause of cancer death in American men with deaths and new cases estimated in the US in Radiation therapy is one of the standard therapies for high and intermediate risk patients and is a non surgical therapy option for low risk patients A combined chemo radiation therapy CRT approach has been shown in several trials to improve s ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Scaffold to Promote Skin Regeneration

    SBC: FirstString Research, Inc            Topic: NIAMS

    PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Skin Microbiome Editing with Fermentation Initiator

    SBC: Surface Bioadvances, Inc.            Topic: NIAMS

    Abstract Acne dysbiosis is defined as microbial imbalance with the over growth of Propionibacterium acnes P acnes in the acne microbiome We have demonstrated that Staphylococcus epidermidis S epidermidis a probiotic bacterium co existed with P acnes in an acne lesion can exploit the carbohydrate fermentation to produce short chain fatty acids SCFAs and rein in the over growth of P ac ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Neuro Optical Diagnostic System for Macular Degeneration

    SBC: NEUROFIELDZ INC.            Topic: NIA

    Age related macular degeneration AMD causes progressive loss of central vision and is the leading cause of blindness in the developed world A major challenge in the development of effective treatments for AMD is the lack of sensitive practical visual function endpoints People with AMD manifest delayed dark adaptation DA recovery and DA tests are a FDA approved method for diagnosing AMD Cu ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Therapeutic game based exercise during hemodialysis to improve balance and mobility

    SBC: BioSensics LLC            Topic: NIA

    Abstract Chronic kidney disease CKD disproportionately impacts older adults Balance mobility and falls are serious problems for CKD patients due to associated peripheral neuropathy and peripheral arterial disease which also contribute to foot ulcers and other foot problems in this population Among older adults these problems are often compounded by other comorbid conditions leaving older ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Treatment for Traumatic Brain Injury

    SBC: Epigen Biosciences, Inc.            Topic: 101

    SUMMARY Traumatic brain injury TBI is a leading contributor to death and disability in the USA yet widely effective treatments remain elusive and except for a lengthy program of rehabilitation no effective treatment for TBI is available Therefore there is a critical need in new therapeutic approaches which can maximally preserve brain tissue and facilitate functional recovery after TBI In ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Online Practitioner Training in Behavioral Intervention in Autism Skill Training Using an Interactive Simulated Child

    SBC: Praxis            Topic: 104

    Project Summary Autism Spectrum Disorder ASD is a complex neurological disorder that typically appears before the age of three and immediately and profoundly affects a young childandapos s ability to communicate develop language form social relationships and respond appropriately to environmental cues Behavioral intervention is a consensus andquot best practiceandquot scientific treatment me ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Pirenzepine for HIV SN

    SBC: WinSanTor, Inc.            Topic: 101

    PROJECT SUMMARY Over million people worldwide including million people in the USA are HIV positive HIV associated sensory neuropathy HIV SN is the most frequent neurological manifestation of HIV and is characterized as a distal symmetrical predominantly sensory polyneuropathy HIV SN may represent clinically indistinguishable neuropathies with distinct pathogenesis a distal axona ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Quantitative Non Invasive Brain Imaging using Magnetic Nanoparticles

    SBC: TheraNano LLC            Topic: NIDA

    This Phase I STTR project is based upon a new technique Quantitative Ultra short Time to Echo Contrast Enhanced QUTE CE MRI utilizing UTE sequences with SuperParamagnetic Iron Oxide Nanoparticles SPION that leads to quantifiable vascular images with unprecedented clarity and definition QUTE CE is particularly optimal using Ferumoxytol an FDA approved iron oxide nanopharmaceutical The techni ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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