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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Therapeutic Intermittent Compression Socket

    SBC: LIBERATING TECHNOLOGIES INC            Topic: N/A

    The purpose of this project is to develop a device that provides rapid intermittent compression to the residual limb of amputees that do not have good blood flow in their limbs. The device will be built into the prosthetic socket to provide the user with portable therapy throughout the day, which will free the user from being confined to a chair for up to six hours each day to receive the prescrib ...

    SBIR Phase I 2014 Department of Education
  2. Development and Evaluation of the Online and Applied System for Intervention Skills (OASIS) Program for the Supervision of Professionals Working with Young Children with Autism.

    SBC: BEHAVIORAL TECHNOLOGIES CONSULTING ORGANIZATION, INC            Topic: N/A

    This project seeks to develop and evaluate a pilot version of the Online and Applied System for Intervention Skills – Supervision (OASIS-S) a cloud-based portal for the supervision of individuals in service fields that require post-degree supervision. Initially two modules (online and skill-based activities) will be developed for those seeking certification as behavior analysts. This system inco ...

    SBIR Phase I 2014 Department of Education
  3. Development of Gap Junction Inhibition Therapy for Alcoholic Liver Disease

    SBC: HEPROTECH, INC.            Topic: NIAAA

    ? DESCRIPTION (provided by applicant): Alcoholic liver disease is a highly prevalent and costly condition affecting millions of people globally. Alcohol results in high morbidity and mortality an is responsible for nearly 4% of all deaths worldwide. Despite the tremendous societal and economic burden, there is no approved therapeutics for alcoholic liver disease. Instead, the standard of care ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Clinically suitable approach for gene-mediated therapy of cirrhosis.

    SBC: ADVANTAGENE, INC            Topic: NIAAA

    Abstract Persistent injury to the liver can cause chronic inflammation and dysregulated deposition of extracellular matrix (ECM), leading to accumulation of fibrotic scar tissue and eventually cirrhosis. While fibrosis is a normal wound healing response, in excess, it can further injure tissue and activate pro-fibrotic cells, resulting in a positive feedback loop. Scar tissue is not static, ECM re ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Algorithm for Free Testosterone Determination

    SBC: FUNCTION PROMOTING THERAPIES LLC            Topic: NIA

    DESCRIPTION (provided by applicant): The measurement of testosterone levels is central to the diagnosis of androgen disorders in men and women. Circulating testosterone is bound largely to sex hormone binding globulin (SHBG) and albumin; only the unbound or free fraction is biologically active. Therefore, in conditions that affect SHBG concentrations, such as aging, obesity, and diabetes, the dete ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. A turn-key optogenetics and electrophysiology measurement system

    SBC: Pinnacle Technology, Inc.            Topic: NIA

    ABSTRACT Age-related sleep problems such as advanced sleep phase disorder (ASPD) are estimated to affect at least 1% of middle-aged adults and increase in prevalence with age. While the detrimental effects of sleep disruption with aging are well characterized, detailed insights into the molecular and physiological mechanisms underlying these sleep changes are greatly lacking. Optogenetics harnesse ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Compounds for Reducing Brain A-Beta Levels via Enhanced Systemic Clearance

    SBC: AKSTON BIOSCIENCES CORPORATION            Topic: NIA

    DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is characterized by progressively worsening dementia eventually leading to death. It affects over five million people in the United States and costs the healthcare system over 200 billion per year. Currently there is no available therapy for slowing, reversing or preventing the disease. There is strong evidence suggesting that AD ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Novel therapeutic for hematopoietic stem cell regeneration in bone marrow post my

    SBC: Minerva Biotechnologies Corporation            Topic: NIAID

    DESCRIPTION (provided by applicant): The purpose of this study is to establish in vivo proof of principle for a human therapeutic for hematopoietic stem cell regeneration in the bone marrow after myeloablation from radiation. Blood stem cells are the mostsusceptible to the effects of radiation and the most lethal. We have already demonstrated proof of principle for our therapeutic in vitro. If suc ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. A Novel Immunotolerizing Therapy for Autoimmune Vitiligo

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Radikal Therapeutics (RTX) is pioneering a novel therapy to restore immune tolerance and arrest progressive depigmentation in vitiligo. At Loyola University (LUC), a variant to inducible Heat Shock Protein 70 was developed with remarkable potential for the prevention and treatment of autoimmune vitiligo. Carrying only a single amino acid modification to the pro ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Novel mechanism-based targeted approach to rheumatoid arthritis

    SBC: SIGNABLOK, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that causes chronic inflammation of the joints. RA affects about 1.5 million Americans and costs society more than 40 billion each year. Despite advances in therapy, RA has no cure. Current treatments of RA include non-steroidal anti- inflammatory drugs, corticosteroids, and disease modifyi ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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