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Age related macular degeneration AMD causes progressive loss of central vision and is the leading cause of blindness in the developed world A major challenge in the development of effective treatments for AMD is the lack of sensitive practical visual function endpoints People with AMD manifest delayed dark adaptation DA recovery and DA tests are a FDA approved method for diagnosing AMD Cu ...

Abstract Chronic kidney disease CKD disproportionately impacts older adults Balance mobility and falls are serious problems for CKD patients due to associated peripheral neuropathy and peripheral arterial disease which also contribute to foot ulcers and other foot problems in this population Among older adults these problems are often compounded by other comorbid conditions leaving older ...

In the proposed study we will develop and evaluate a product called My MESSAGE Multimedia Ecopsychosocial Support System for Alzheimer s within Geriatric Environments which will circumvent the limitations of traditional visual cues and also provide unprecedented flexibility and precision for assisting with wayfinding and reducing other challenging behaviors in PWD The target consumer for MM w ...

Prostate cancer PCa is the second leading cause of cancer death in American men with deaths and new cases estimated in the US in Radiation therapy is one of the standard therapies for high and intermediate risk patients and is a non surgical therapy option for low risk patients A combined chemo radiation therapy CRT approach has been shown in several trials to improve s ...

The binding sites of proteins include smaller regions called hot spots that are major contributors to the binding free energy and hence are crucial to binding any ligand at that site Hot spots can be determined by screening libraries of fragment sized organic molecules for binding to the target protein by X ray crystallography or nuclear magnetic resonance NMR The computational mapping algori ...

Millions of U S adults suffer from a co occurring mental health and substance use disorder COD A COD is often difficult for providers to address and thus clients may experience poor treatment engagement symptom exacerbations homelessness incarceration and often utilize acute and emergency services increasing medical expenditures Currently the healthcare delivery system needs but does ...

PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

This Phase I STTR project is based upon a new technique Quantitative Ultra short Time to Echo Contrast Enhanced QUTE CE MRI utilizing UTE sequences with SuperParamagnetic Iron Oxide Nanoparticles SPION that leads to quantifiable vascular images with unprecedented clarity and definition QUTE CE is particularly optimal using Ferumoxytol an FDA approved iron oxide nanopharmaceutical The techni ...

Herpes simplex viruses and HSV HSV cause a wide range of significant diseases including oral genital lesions corneal blindness and encephalitis HSV and HSV are both transmitted sexually and can infect babies during birth Therapy for HSV relies primarily on nucleoside analogs such as acyclovir ACV which are insufficiently effective and resistant viruses are becoming common amo ...

Intoxication from marijuana MJ impairs psychomotor performance and at least doubles the risk of motor vehicle accidents The ongoing wave of legalization of MJ has brought increasing prevalence of driving while intoxicated with MJ However there is no quantitative biologic test that can accurately determine whether an individual is acutely impaired from MJ intoxication Assays of the primary in ...