Award Data

ABSTRACT: The Phase II technical objectives follow directly from the Phase I effort, where all tasks necessary for RF photonic receiver fabrication were demonstrated. The Phase II effort will pursue two major objectives: 1) further development of SEO100 EO polymer based chips, packaged devices and arrays in collaboration with University of Dayton (antenna designs), taking advantage of multiphoto ...

ABSTRACT: AdValue Photonics and University of Arizona propose to demonstrate the capability of fabricating wavelength division multiplexers (WDM) for high-power fiber laser applications. It is based on AdValue Photonics"unique fused fiber technology using large-mode-area (LMA) fibers. Both polarization-maintaining (PM) and non-PM LMA fiber WDMs will be fabricated. By the end of Phase I, two proto ...

ABSTRACT: In ISR applications, multiple sensors can be employed to achieve more accurate parameters of interest on targets, improving discrimination and detection. But, the proliferation of sensor systems has created a large volume of multi-sensor data across a number of physical spectra. These resulting measurements can be so disparate that traditional aggregation methods perform poorly given h ...

ABSTRACT: The overall technical objective of this Phase II effort is to develop computational tools for computing response sensitivities of parametric multi-disciplinary air vehicle systems that exhibit nonlinear dynamic behavior for use in gradient-based optimization, smart sampling, uncertainty quantification, and risk assessment. To this end, the ZONA/MIT team will extend the 2-D ZEUS time-dom ...

DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a devastating neurodegenerative disorder. One of the few drugs used to treat AD is memantine, which inhibits N-methyl-d-aspartate receptors (NMDARs), glutamate receptor subtypes found at nearly all vertebrate excitatory synapses. NMDARs are critically involved in many aspects of nervous system function, including learning and me ...

DESCRIPTION (provided by applicant): About 3-4% of all fractures are estimated to be open fractures, where the fracture is exposed through defects in the skin and soft tissues. This equates to about 250,000 open fractures in the United States annually. Open fractures present a high risk of infection. Infection results in considerable financial burden to both the patient an healthcare system, requ ...

DESCRIPTION (provided by applicant): The major barriers limiting the application of MRI to detect small liver lesions and metastasis at the early stage and patient selection for targeted therapy based on molecular imaging of disease biomarkers, are due tothe lack of desired MRI contrast agents capable of enhancing the contrast between normal liver tissues and tumors with high relaxivity, tumor tar ...

DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

DESCRIPTION (provided by applicant): Due to its asymptomatic nature and lack of methods for early detection, gt 80% of pancreatic cancer (PC) patients present with an unresectable primary tumor with distant metastasis at the time of diagnosis. While the overall 5 year survival rate of pancreatic cancer is dismal, significantly better outcomes have been reported for smaller tumors detected at an e ...

? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...