Award Data

DESCRIPTION provided by applicant The product is a slide coated with silica colloidal crystals to combine protein electrophoresis with matrix assisted laser desorption ionization mass spectrometry MALDI MS detection giving superior performance in both The Phase II proposal will be to develop an instrument for facile application of the slide in proteomics of intat glycoproteins This propos ...

DESCRIPTION provided by applicant Widespread antibiotic use has accelerated S aureus resistance to almost all marketed antibiotic classes including beta lactams fluoroquinolones macrolides aminoglycosides tetracyclines as well as the newer linezolid and daptomycin Methicillin resistant S aureus MRSA is an increasing public health threat with deaths from MRSA infections already compar ...

DESCRIPTION provided by applicant This is a collaborative proposal to develop inhibitors with reduced susceptibility to resistance and improved genotype spectrum of activity against the NS A protease of the Hepatitis C virus HCV Over three percent of the worldandapos s population is infected with the hepatitis C virus HCV Unfortunately the current best treatment is still quite challeng ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

Two-electron reduced-density-matrix (2-RDM) methods represent all of the electrons in any molecule or material with only two electrons by replacing the wave function by the 2-RDM as the basic variable for quantum many-electron theory. The 2-RDM methods, developed by David Mazziotti at The University of Chicago with support from the Army Research Office, have polynomial scaling with system size, al ...

MicroLink Devices and the University of Notre Dame propose to develop an ultra-lightweight, high-efficiency, GaAs-based, multi-junction solar cell that will be suitable for use in future platforms requiring very high specific power (>3.0 kW/kg) and very high areal power density (>370 W/m2). We will achieve this result by reducing the metal content of MicroLinks current inverted metamorphic (IMM), ...

Active Electronic Scanned Array (AESA) radars play a strategic role in surveillance and reconnaissance. A GaN based T/R circuit will be radiation-hard but difficult to integrate with the remainder of the signal chain due to incompatible technologies. SiGe HBT technology, with its high frequency performance and the ability to blend in with CMOS, can act as a bridge between the high frequency III-V ...

American Energy Technologies Co. (a woman-owned small business concern of Arlington Heights, IL), will be joined by subcontractors University of Massachusetts (Boston, MA) and Advanced Technology Laboratories of Lockheed Martin Corp. (St. Paul, MN) in order to develop two anti-corrosion technologies with the goal to deploy them in a variety of equipment. The first technology is a top coating whic ...

The primary goal of this proposed effort is to develop mid-wavelength infrared (MWIR) colloidal quantum dot (CQD)-based focal plane arrays (FPAs) to significantly reduce the cost of MWIR photon imagers. In order to realize this goal, it will first be nec

ABSTRACT: MicroLink and its collaborators, Rochester Institute of Technology and Magnolia Solar, will develop a high-efficiency, single-junction, epitaxial lift-off (ELO) GaAs solar cell by incorporating nano-scale features, such as quantum dots and optically functional textures, within the solar cell structure. The principal technical objective of the project is to increase the AM0 efficiency o ...