Award Data

ABSTRACT: MicroLink and its collaborators, Rochester Institute of Technology and Magnolia Solar, will develop a high-efficiency, single-junction, epitaxial lift-off (ELO) GaAs solar cell by incorporating nano-scale features, such as quantum dots and optically functional textures, within the solar cell structure. The principal technical objective of the project is to increase the AM0 efficiency o ...

ABSTRACT: CU Aerospace (CUA) and team partner the University of Illinois at Urbana-Champaign (UIUC) propose to perform research, development and demonstration of experimental quenching free measurements of heat-release in a realistic highly turbulent plasma-assisted flame. Kinetics models will be correspondingly updated and detailed 3D multiphysics simulations will be validated by the measuremen ...

ABSTRACT: Living systems rely on pervasive vascular networks to enable a plurality of biological function, exemplified by natural composite structures that are lightweight, high-strength, and capable of mass and energy transport. In contrast, synthetic composites possess high strength-to-weight ratios but lack the dynamic functionality of their natural counterparts. CU Aerospace, with team partne ...

ABSTRACT: In ISR applications, multiple sensors can be employed to achieve more accurate parameters of interest on targets, improving discrimination and detection. But, the proliferation of sensor systems has created a large volume of multi-sensor data across a number of physical spectra. These resulting measurements can be so disparate that traditional aggregation methods perform poorly given h ...

DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

DESCRIPTION (provided by applicant): AuraSense Therapeutics (AST), along with Northwestern University, is applying a recently developed technology using oligonucleotide-functionalized nanoparticles (called spherical nucleic acids or SNAs) to control protein expression. These easily synthesized nanoparticles can have either DNA or RNA shells, and are less than 50 nm in hydrodynamic diameter. SNA co ...

Project Summary The goal of this STTR grant application is to engineer powerful NK cell-based cytolytic effector cells for therapeutic applications. The cells will combine the selectivity and specificity of T cells and the ability of NK cells to mediate effective cytolytic activity against a wide spectrum of aberrant cells, including those with impaired adhesion properties. To achieve this goal we ...

DESCRIPTION (provided by applicant): Due to its asymptomatic nature and lack of methods for early detection, gt 80% of pancreatic cancer (PC) patients present with an unresectable primary tumor with distant metastasis at the time of diagnosis. While the overall 5 year survival rate of pancreatic cancer is dismal, significantly better outcomes have been reported for smaller tumors detected at an e ...

DESCRIPTION (provided by applicant): Genomic instability is a hallmark of cancer, yet is underdeveloped as a therapeutic target area The central goal of this program is to develop new cancer therapeutics that target genomic instability as a hallmark of cancer cells, bringing new, cancer-cell selective treatments to the clinical oncology market. Two key challenges in current cancer therapy are mini ...

? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...