Award Data

DESCRIPTION provided by applicant Leptospirosis a zoonotic disease is an important public health problem worldwide It is caused by spirochete bacteria belonging to nine species and more than serovars of the genus Leptospira In the US there is increasing awareness of the importance of leptospirosis as the cause of disease among inner city populations military personnel and individuals ...

DESCRIPTION provided by applicant This proposal seeks to develop a novel vaccine against Lyme disease by targeting Ixodes scapularis proteins critical for Borrelia burgdorferi transmission from the tick to mammalian host Earlier work has identified four tick proteins Salp TRE tHRF and TSLPI that facilitate different steps of spirochete transmission and immunity against these protein ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Approximately one third of all U S adults and children are obese and at risk for a wide range of related chronic health conditions such as cardiovascular disease hypertension diabetes stroke osteoarthritis sleep apnea and certain types of cancer The Center for Disease Control and Prevention CDC and other expert resources recognize that although indivi ...

The objective of this technology transfer effort is to leverage technology developed at Savannah River National Laboratory (SRNL) to develop a portable proportional counter (PC) for neutron detection. NanoTechLabs Inc. (NTL) will develop a portable proportional counter for neutron detection utilizing nanostructured field emitters. Unlike traditional proportional counters, which are typically arran ...

Current and next-generation power systems require power devices that operate at high voltages and high frequencies beyond the reliable operating limit of the present silicon- and silicon carbide-based power devices. The material properties of AlN permit power devices to operate at these extremes, promoting device shrinkage for automotive applications as well faster switching and more efficient pow ...

Access to clean water is a global problem that has led to the development of multiple desalination techniques. All techniques strive to reduce the cost of desalinating water to provide clean water in a cost effective manner. Capacitive deionization (CDI) is a new technique that can reduce the cost of ownership by ~85% compared with reverse osmosis for brackish water. This project will further im ...

In order to dramatically reduce CO2 emissions from coal-fired power plants, and mitigate their impact on global climate change, DOE has called for technologies that can capture at least 90% of CO2 emissions from an existing coal-fired power plant with no more than a 35% increase in the cost of electricity (COE). One process design approach with the potential to achieve these goals is through the u ...

The problem/situation that is being addressed is the development and improvement of compact laser- driven x-ray sources for ultrafast characterization of interest to the DoE. While much progress has been made in the development of table-top x-ray sources, with high harmonic sources and atomic soft x-ray lasers presently allowing for a large number of experiments to be conducted in small laborator ...