Award Data

DESCRIPTION provided by applicant Leptospirosis a zoonotic disease is an important public health problem worldwide It is caused by spirochete bacteria belonging to nine species and more than serovars of the genus Leptospira In the US there is increasing awareness of the importance of leptospirosis as the cause of disease among inner city populations military personnel and individuals ...

DESCRIPTION provided by applicant This proposal seeks to develop a novel vaccine against Lyme disease by targeting Ixodes scapularis proteins critical for Borrelia burgdorferi transmission from the tick to mammalian host Earlier work has identified four tick proteins Salp TRE tHRF and TSLPI that facilitate different steps of spirochete transmission and immunity against these protein ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Approximately one third of all U S adults and children are obese and at risk for a wide range of related chronic health conditions such as cardiovascular disease hypertension diabetes stroke osteoarthritis sleep apnea and certain types of cancer The Center for Disease Control and Prevention CDC and other expert resources recognize that although indivi ...

The ability to detect radiological materials at standoff distances of a kilometer or more would be invaluable to national security and nonproliferation efforts. In particular, it is important to be able to distinguish isotopes of uranium and other elements associated with nuclear weapons development and use. Current methods for identifying radiological isotopes require direct sampling. Laser ba ...

As part of its mission to understand the fundamental forces and particles of nature as manifested in nuclear matter, DOE is funding an experiment to measure the electric dipole moment of neutron. This sophisticated experiment tests the standard model by monitoring the response of neutrons in crossed electric and magnetic fields. This Phase I project will investigate a method for measuring the str ...

The objective of this technology transfer effort is to leverage technology developed at Savannah River National Laboratory (SRNL) to develop a portable proportional counter (PC) for neutron detection. NanoTechLabs Inc. (NTL) will develop a portable proportional counter for neutron detection utilizing nanostructured field emitters. Unlike traditional proportional counters, which are typically arran ...

Current and next-generation power systems require power devices that operate at high voltages and high frequencies beyond the reliable operating limit of the present silicon- and silicon carbide-based power devices. The material properties of AlN permit power devices to operate at these extremes, promoting device shrinkage for automotive applications as well faster switching and more efficient pow ...

Metal casting is an important manufacturing process and most castings are made by small to mid-sized foundries. Sand molded castings account for 85% of all iron and steel castings produced and approximately 5 out of 30 major casting defects including gas blows and sand burn-on are related to poor sand mold atmosphere control. Mold atmosphere control should become more crucial in the coming years a ...