Award Data

DESCRIPTION provided by applicant Leptospirosis a zoonotic disease is an important public health problem worldwide It is caused by spirochete bacteria belonging to nine species and more than serovars of the genus Leptospira In the US there is increasing awareness of the importance of leptospirosis as the cause of disease among inner city populations military personnel and individuals ...

DESCRIPTION provided by applicant This proposal seeks to develop a novel vaccine against Lyme disease by targeting Ixodes scapularis proteins critical for Borrelia burgdorferi transmission from the tick to mammalian host Earlier work has identified four tick proteins Salp TRE tHRF and TSLPI that facilitate different steps of spirochete transmission and immunity against these protein ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

DESCRIPTION provided by applicant Approximately one third of all U S adults and children are obese and at risk for a wide range of related chronic health conditions such as cardiovascular disease hypertension diabetes stroke osteoarthritis sleep apnea and certain types of cancer The Center for Disease Control and Prevention CDC and other expert resources recognize that although indivi ...

The objective of this technology transfer effort is to leverage technology developed at Savannah River National Laboratory (SRNL) to develop a portable proportional counter (PC) for neutron detection. NanoTechLabs Inc. (NTL) will develop a portable proportional counter for neutron detection utilizing nanostructured field emitters. Unlike traditional proportional counters, which are typically arran ...

Current and next-generation power systems require power devices that operate at high voltages and high frequencies beyond the reliable operating limit of the present silicon- and silicon carbide-based power devices. The material properties of AlN permit power devices to operate at these extremes, promoting device shrinkage for automotive applications as well faster switching and more efficient pow ...

Energy usage will continue to increase at a dramatic pace for the foreseeable future, endangering the security, economy, and environment of the nation. One means of meeting this challenge is the replacement of liquid transportation fuels based on petroleum with cellulosic bioethanol. However, cellulosic ethanol remains too costly to be commercially feasible, in part due to the generation of orga ...

Lithium-ion batteries are promising energy storage devices for hybrid and electric vehicles, providing high specific energy (approximately 150 Wh/kg), energy density (approximately 400 Wh/L), and long cycle life (greater than 15 years). However, these applications require further increases in energy density and improved low-temperature (less than ¿10 degrees C) performance. Silicon-based anod ...

This project will develop inexpensive and environmentally benign LiMnPO4 cathodes for applications to lithium-ion batteries (LIB) used in electric and hybrid electric vehicles. This cathode material is expected to be far safer than Li-ion batteries employing traditional layered LiMO2 (M=Co, Ni) materials. A number of synthetic modifications will be pursued to optimize the LiMnPO4 material for us ...

Advanced SiC-based high-power switches are need for power conversion applications. This project will develop a 10 kV-18 kV class, high voltage, SiC Emitter Turn-off thyristor that maximizes the capability of SiC materials while minimizing the effect of immature material properties, such as poor oxide reliability and low surface mobility. The SiC ETO will result in the best performance in terms o ...