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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel Tissue Protector for Subarachnoid Hemorrhage

    SBC: COGNOSCI INC            Topic: N/A

    DESCRIPTION (provided by applicant): There are approximately 30,000 new cases of aneurysmal subarachnoid hemorrhage (SAH) in this country, making it a significant health care problem. Despite advances in the medical and surgical care of patients with SAH, this condition still has a high morbidity and mortality, with a 30 day mortality of nearly 50%. In order to examine the pathophysiology of vasos ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  2. Mapping disease-specific human protein networks

    SBC: Curagen Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): While the human genome sequence is known, medical advances will require knowledge of how individual genes and proteins assemble into functional biological networks. These networks are built in part through physical interactions between proteins. Protein interaction networks can now be probed using highthroughput experimental methods, yet challenges remain: dat ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Genetic Therapy for CF in a CF Rabbit

    SBC: EVERGEN BIOTECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The development of transgenic mouse models for cystic fibrosis (CF) has been an important contribution to our understanding of CF and of CF transmembrane conductance regulator (CFTR) function. However, because of the dissimilarity between mouse and human anatomy and physiology, there are limitations in what can be discerned about CF pathology and in development ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Bioreactor for Engineered Bioartificial Tissues (BATS)

    SBC: Flexcell International Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Few commercial bioreactors are available for the culture of three dimensional (3D) tissues. Flexcell's strategy is to provide a commercial bioreactor allowing ease of operation to produce molded 3D tissue constructs in cell- populated matrix gels of variable geometries with controlled nutrient perfusion and mechanical stimulation. This design is based on a vali ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  5. A Novel Protection Device for Shock Wave Lithotripter

    SBC: Genognomon, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The shock wave lithotripsy (SWL) was first introduced successfully in clinical treatment in the earlier 1980s by Dornier Medical System in Germany. Now it has become the modality for urolithiasis diseases. However, SWL also causes acute renal injury, such as hemorrhage, hematoma, edema and enlargement of kidney. Although most patients recover well following ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  6. A Worldwide Research Network of Dynamic Cardiac Images

    SBC: HEART IMAGING TECHNOLOGIES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Phase I of a fast-track STTR application submitted in response to Program Announcement PA-03-001 ("Knowledge Integration across Distributed Heterogeneous Data Sources"). We propose a collaborative effort between Heart Imaging Technologies, LLC (HeartIT) and Duke University's Cardiovascular Magnetic Resonance Center (DCMRC). The goal of the collaborati ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Protection Against West Nile Virus by RNA Interference

    SBC: L2 DIAGNOSTICS LLC            Topic: N/A

    DESCRIPTION (provided by applicant): West Nile (WN) virus is a flavivirus that can cause fatal human encephalitis. Over the past four years, this virus has established itself across the United States. There are no approved vaccines or therapies to protect against WN virus. This project is designed to develop an effective anti-WN virus RNA interference therapy. Our hypothesis is that small interfer ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Diffraction Enhanced Imaging Laboratory Research Machine

    SBC: Nesch, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Diffraction enhanced imaging (DEI) is a novel approach to X-ray imaging that has the potential to revolutionize X-ray medical imaging, because of its greater contrast at lower delivered X-ray doses than conventional radiography. DEI relies on measuring tiny angular deflections of a collimated X-ray beam as it passes through the object (patient) in acquiring the ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  9. Investigation of Shape Memory Polymers in Orthodontics

    SBC: New Ortho Polymers            Topic: N/A

    DESCRIPTION (provided by applicant): All orthodontic treatment is based on the application of optimal forces that minutely displace teeth initiating a biological response that alters both hard and soft tissues. Because of the precision of control, most treatment is carried out with fixed appliances that are capable of delivering forces and moments to the crowns of teeth. More limited treatment an ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Interactive Cell-phone tech for Health Enhancement

    SBC: Palaistra Systems, Inc.            Topic: N/A

    The burden of chronic disease in the United States is formidable, with 70% of all deaths attributable to some form of chronic illness. As the majority of chronic diseases arise from, and vary in severity with, modifiable behaviors, self-care has enormous potential to ameliorate their course; however, adherence to self-care plans is often poor. Advances in technology can empower patients in novel w ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
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