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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Using a novel model of antidepressant efficacy to discover new compounds and personalized treatments.

    SBC: PAX NEUROSCIENCE, INC.            Topic: 102

    The World Health Organization estimates that bymajor depressive disorderMDDwill be the most common cause of disabilityworldwideAlthough approximatelyinAmericans will suffer from MDD during their lifetimemany patients with MDD go undiagnosed in primary care settingsandare incorrectly diagnosed with MDDGiven the substantial medicaleconomic and social costs involved with MDDthere is tremendous need f ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Wireless implantable optofluidic systems for programmed pharmacology and optogenetics

    SBC: Neurolux, Inc.            Topic: 101

    Project Summary Abstract Diseases of the central and peripheral nervous systems affect the quality of life of millions of people worldwide Progress in understanding the function of neural networks and in developing associated insights into the underlying causes of these diseases can be accelerated by advances in techniques and methodologies for neuroscience research Collaborative efforts between ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Ultrasound Based Device to Guide Treatment of Graft Versus Host Disease Using Skin Elasticity as a Biomarker

    SBC: Microelastic Ultrasound Systems, Inc.            Topic: 102

    Ultrasound Based Device to Guide Treatment of Graft Versus Host Disease using Skin Elasticity as a Biomarker ABSTRACT Sclerotic chronic graft versus host disease cGVHD develops in of allogenic Human Stem Cell Transplant HCT recipients and is associated with significant morbidity and mortality GVHD is treated with immunosuppression which puts patients at severe risk of infection ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Study of the New HDAC i SW as a Treatment for Alzheimer's Disease and Other Tauopathies

    SBC: Starwise Therapeutics LLC            Topic: NIA

    ABSTRACT Alzheimerandapos s and other tauopathies are medical problems growing to historical proportions that threaten the long term viability of medical care systems world wide Alzheimerandapos s costs today are of the US GDP and growing as the population ages Effective disease modifying treatments have yet to be developed A number of drugs in clinical testing target amyloid but very fe ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Novel Hernia Mesh to Improve Anchor Point Fixation and Prevent Hernia Formation

    SBC: Deep Blue Medical Advances, Inc.            Topic: 300

    Abstract Two million laparotomies are performed annually in the U S with ventral hernia being a frequent complication in of patients The average cost patient for each hernia operation in the U S in was $ which amounts to $ billion annually The ten year ventral hernia recurrence rate is There are $ B in hernia meshes sold annually in the United States With ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Prognosis an interactive digital public health and epidemiology adventure

    SBC: RESILIENT GAMES STUDIO, LLC            Topic: OD

    Project Abstract The proposed Phase I STTR project will develop the serious game Prognosis and its supporting website to improve systems thinking and problem solving through learning about public health and epidemiology Prognosis is a simulation game that focuses on the population health of the fictional city Hexacago Through game play players will learn how multiple ambient citywide systems ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a POEGMA Aptamer rapid onset anticoagulant that eliminates antigenicity to anti PEG antibodies

    SBC: Gateway Bio, Inc.            Topic: NHLBI

    ABSTRACT The objective of this STTR proposal is to reformulate a promising PEG aptamer rapid onset anticoagulant ROA by applying a novel PEG like POEGMA polymer brush technology capable of eliminating anti PEG antigenicity The importance of this proposal is highlighted by the early termination of a recent Phase III clinical trial of the original PEG aptamer conjugate in which severe allergic ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Scaffold to Promote Skin Regeneration

    SBC: FirstString Research, Inc            Topic: NIAMS

    PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. The Patient Centered Postpartum Contraception ToolKit PC

    SBC: RESILIENT GAMES STUDIO, LLC            Topic: NICHD

    Project Abstract Short interpregnancy intervals IPIs pose risks for mothers and newborns alike including preterm birth low birth weight small for gestational age and placental abruption IPIs of less than months increase risk of neonatal death Short IPIs are a source of major health disparities and disproportionately affect African American adolescents Postpartum contraception signific ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Creation of animal models of mitochondrial DNA disease for translational research applications

    SBC: ENZERNA BIOSCIENCES LLC            Topic: 400

    Mitochondria are the principal generators of cellular ATP by oxidative phosphorylation which links electron transport via Complexes I through IV to production of ATP via ATP synthase Over pathogenic human mitochondrial DNA mtDNA mutations associated with diseases ranging from cardiomyopathy to juvenile blindness have been identified Collectively millions are affected by mtDNA disease fo ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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