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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. PLATFORM FOR NEUROCOGNITIVE EVALUATION AND MONITORING

    SBC: ENFORMIA INC.            Topic: NCI

    Current standardized neuropsychological tests are based on decades old paper and pencil methods They lack reliability sensitivity specificity repeatability and require trained neuropsychologists to administer them Their administration in clinical and research settings result in high cost complexity and inconsistent results There is a need and a commercial opportunity for an extensible co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A high throughput sample preparation platform for genomic and epigenetic analysis

    SBC: MATCHSTICK TECHNOLOGIES INC            Topic: 200

    Several types of cancers e g pancreatic and brain malignancies remain extremely lethal despite the introduction of chemotherapy more than years ago The hallmark of all cancers are somatic mutations which cannot be corrected In sharp contrast epigenetic changes essential contributors to tumorigenesis are pharmacologically reversible The ability to remedy detrimental epigenetic alteratio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. A Phase Clinical Trial Evaluating the Novel Small Molecule Immuno Oncology Antagonist SX Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCR and CXCR CXCR are validated as having essential roles in the growth survival motility invasion and angiogenesis of human melanoma which secretes abundant amounts of the corresponding chemokine ligands including CXCL Additionally abnormal cancer induced immunosuppressive myeloid derived suppressor cells MDSCs in the circulation and tumor correlate with ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Immuno-Chemotherapy to Shorten TB Treatment

    SBC: PAI LIFE SCIENCES INC            Topic: NIAID

    DESCRIPTION provided by applicant Tuberculosis TB a disease caused by Mycobacterium tuberculosis Mtb is an ongoing threat to public health Globally approximately two billion people are infected with TB with nine million newly diagnosed cases of active TB each year causing million deaths Furthermore mismanagement or inappropriate treatments for TB infections can result in the deve ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Nitric Oxide Microfluidic Sensor

    SBC: CLINICAL SENSORS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant This Small Business Innovation Research SBIR Phase I project aims to develop a microfluidic based nitric oxide NO sensor as an early sepsis risk assessment device Sepsis causes significant strain on the U S healthcare system consuming over $ billion annually due to extended hospital stays and significant morbidity and mortality Rapid diagnosis and in ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. RNA Detection as an Improved Diagnostic Assay for Human Leptospirosis

    SBC: L2 DIAGNOSTICS LLC            Topic: NIAID

    DESCRIPTION provided by applicant Leptospirosis a zoonotic disease is an important public health problem worldwide It is caused by spirochete bacteria belonging to nine species and more than serovars of the genus Leptospira In the US there is increasing awareness of the importance of leptospirosis as the cause of disease among inner city populations military personnel and individuals ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. XRpro Radioactive Cesium Decorporation Agents

    SBC: Icagen, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Caldera aims to develop an inexpensive stable selective decorporation decorp agent for cesium Cs Cs is easily obtainable by terrorists and treatments for exposures are Project Bioshield priorities for use in radiation nuclear emergencies high priority for DHHS NIH NIAID DAIT and a critical need for the Strategic National Stockpile S ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. A Multivalent Lyme Disease Vaccine Targeting Tick-Host-Pathogen Interactions

    SBC: L2 DIAGNOSTICS LLC            Topic: NIAID

    DESCRIPTION provided by applicant This proposal seeks to develop a novel vaccine against Lyme disease by targeting Ixodes scapularis proteins critical for Borrelia burgdorferi transmission from the tick to mammalian host Earlier work has identified four tick proteins Salp TRE tHRF and TSLPI that facilitate different steps of spirochete transmission and immunity against these protein ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Medical countermeasure after radiation exposure

    SBC: PHARMAIN CORPORATION            Topic: NIAID

    DESCRIPTION provided by applicant New treatments for radiation injury to the GI tract are desperately needed to ensure survival after exposure to ionizing radiation arising from accident nuclear warfare or terrorist attacks dirty bombs Radiation injuries to the hematopoietic system and the GI tract are fatal with the latter more acutely fatal No treatment is available fo the more acute l ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Direct visualization assay for detection of B. burgdorferi in early Lyme Disease

    SBC: RareCyte, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Lyme disease a tick borne infection caused by the spirochete Borrelia burgdorferi has expanded to an estimated US cases per year Currently approved tests of immune response are sub optimal and often give negative results early in the disease The research outlined in this application is to develop a diagnostic blood test that directly visualizes B b ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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